wow another test Flashcards
Gene
A section of DNA’s nucleotides (a unit of heredity).
DNA VS. RNA Bases
Thymine VS. Uracil
Sequence of Translation
1) mRNA leaves nucleus to ribosome
2) mRNA codon pairs with complementary tRNA anti-codon
3) tRNA brings amino acids to ribosome
4) Amino acids are brought and connected to form a protein
Spindle Fibers
What divides genetic material in a cell when connecting to the centrioles (also known as a microtubules)
Centromere
Part of a chromosome that holds the two chromatids together
Gregor Mendel
1) Discovered DNA in 1869
2) Discovered complete dominance inheritance patterns
Erwin Chargaff
Discovered base pair levels are almost always equal
Rosalin Franklin
Used a technique called X-Ray Diffraction to see the molecule of DNA
James Watson
Showed Rosalin Franklin’s photo in 1953 (known as Picture 51)
Francis Crick
Worked with James Watson to make a model that showed how DNA
1) Carried Info
2) Could be copied
What Creates a Chromosome’s Shape?
DNA’s spirals
Who Proposed Complimentary Base Pair Rules?
James Watson and Francis Crick
Four Base Pairs in DNA
Adenine, thymine, guanine, and cytosine
James Watson’s Lifetime
June 1928 - present
Francis Crick’s Lifetime
July 1916 - July 2004
When Did James Watson and Francis Crick Win the Nobel Prize?
1962
Use of DNA’s Double Helix Shape
1) Protection
2) Continue forming
3) Spiral into chromosome
Heredity
Traits passed down from parents to offspring
Replication Fork
The “active site” where the DNA strand is split into two and DNA replication takes place
Homologous Chromosomes
Chromosomes with the same length, shape, and set of genes
Why Do Cells Divide?
1) Replace old/worn out/dying cells
2) Replace damaged cells
3) Create new cells for growth/development
Interphase
Phase in which the cell prepares for cell division
G1
Gap 1 - Cell grows in size
S
Synthesis - DNA replication
G2
Gap 2 - Organelles are copied and cell prepares for division
G Meaning
Gap - Periods of inactivity and normal metabolic activity
Mitosis
Division of the nucleus (including DNA)
1st Phase of Mitosis
Prophase - Chromosomes condense, nuclear membrane starts to break, spindles form
2nd Phase of Mitosis
Metaphase - Chromosomes align in center and spindle fibers connect
3rd Phase of Mitosis
Anaphase - Chromosomes are divided, cell begins to split
4th Phase of Mitosis
Telophase - Nucleus forms around each group of chromosomes
At the End of Mitosis
There are two separate nuclei
Cytokinesis
Stage where the cytoplasm splits and two separate cells are made
Cytokinesis Looks Different In
Plants versus animal cells
Chromatin
A mixture of DNA and proteins that form chromosomes
Sister Chromatids
The identical copies formed by DNA replication of a chromosome
Centrioles
The organelles that help cells divide (also known as centrosomes)
Stem Cells
Special human cells that develop into many different cell types
Order of Time Mitosis Phases
1) Interphase
2) Anaphase
3) Telophase
4) Metaphase
5) Prophase
Signs of Cancer in Cells
1) Large number of dividing cells
2) Large variably shaped nuclei
3) Large nucleus to cytoplasm ratio
4) Variation in size and shape
5) Loss of normal cell features
6) Disorganized arrangement
7) Poorly defined tumor boundary
Protein Synthesis
How your DNA can lead to the making of protein
Synthesis
To make something
Transcription
DNA to mRNA
Promoter
Region before gene
Translation
mRNA to protein
Introns
Do not code for proteins so are spliced
Splicing
Removing
Exons
Region on mRNA leaves nucleus and codes for protein
Splicesome
ALWAYS removes introns
Alternate Splicing
Randomly removes exons
Genetic Code
1) 20 amino acids
2) 64 possible codon combinations
3) 3 stop codons
Mutation
A change within a nucleic acid
Types of Chromosome Mutations
Duplication, deletion, inversion, and translocation
Inversion
Segment breaks off and reattaches in reverse
Translocation
Segment breaks off and reattaches to different chromosome
Point Mutation
Base-pair substitution
Causes of Mutations
1) Transposable elements
2) During replication
3) Environment
4) Mutagen
Transposable Elements
Segment of DNA that spontaneously moves to another segment
Chromosome
The form DNA takes when it winds up in an organized structure to complete cell division
Nuclear Membrane
The protective layer that surrounds DNA in a eukaryotic cell
One Cell Divides Into
Two diploid cells
Where mRNA, rRNA, tRNA are Found
mRNA - Nucleus and cytoplasm
rRNA - Cytoplasm
tRNA - Cytoplasm
Diploid
Two sets of chromosomes