Wound Repair Flashcards
1
Q
Where are stem cells of the small and large bowel located?
A
Mucousal crypts
2
Q
Granulation tissue formation
A
- Consists of fibroblasts (deposit type III collagen), capillaries (provide nutrients), and myofibroblasts (contract wound)
3
Q
Scar formation
A
Type III collagen replaced with Type I collagen (via collagenase)
note: Zn is a cofactor
4
Q
What are some mediators of regeneration and repair?
A
- TGF-a
- TGF-b
- Platelet derived growth factor
- Fibroblast growth factor (angiogenesis)
- Vascular endothelial growth factor
5
Q
____________ contract the wound and make it smaller.
A
Myofibroblasts
6
Q
Effects of Vitamin C deficiency in wound healing
A
- Decrease in collagen production
- Vitamin C is a cofactor in hydroxylation of proline and lysine procollagen residue
7
Q
Effect of copper defiency in wound healing
A
Unstable collagen; copper is a cofactor for lysyl oxidase, which cross links lysine and hydroxylysine to form stable collagen
8
Q
Keloid is characterized by excess________-.
A
Type III collagen
