Drugs Affecting Adrenergic Function: Agonists Flashcards
Inhibitors of COMT
Entacapone
Tolcapone
Opicapone
Nitecapone
What are the major metabolites of norepinephrine?
- Vanylmandelic acid (VMA)
- Homovanillic acid (HVA)
- 3-methoxy-dopamine
NOTE: These products are usually excreted in the urine and are biologically inactive
What are the diagnostic components of pheochromocytoma?
- Metanephrines (in plasma)
- VMA and HVA (in urine)
Naturally occuring MAO inhibitors
Curcumin
Harmine
Harmaline
Nonspecific MAO inhibitor
Isocarboxazid
__________, the antidote indicated for drug-induced methemoglobinemia, is a highly potent reversible MAO inhibitor.
Methylene blue
MAO-B specific inhibitors
Phenelzine
Selegiline
Tranylcypromine
What are the side effects of MAO inhibtiors?
Hypertensive crisis, dry mouth, nausea, diarrhea or constipation, headache, drowsiness, insomnia, lightheadness
Where are alpha 1 receptors located?
Eye
Arterioles
Veins
Bladder
Prostate
Male sex organs
Liver
Kidney
Where are alpha 2 receptors located?
Prejunctional nerve terminals
Platelets
Pancreas
Where are beta 1 receptors located?
heart SA NODE
AV node
Atrial and ventricular muscle
His-Purkinje
Kidney
Direct acting a1 agonists
Phenylephrine
Methoxamine
Midodrine
Where are beta 2 receptors located?
Blood vessels
Uterus
Bronchioles
Skeletal muscle
Liver
Pancreas
Direct acting alpha 2 agonists
Clonidine
Guanfacine
Guanabenze
Oxymetazoline
Direct acting B1/B2 agonists
Isoproterenol
