Cholinergic Agonists Flashcards
What are the metabolites of cevimeline?
Sulfoxides and glucuronic acid conjugates
What are the cotraindications to the use of choline esters?
- Hyperthyroidism
- Asthma
- Coronary insufficiency
- Peptic ulcer
- organic obstruction in bladder or GI tract
Where is pseudocholinesterase found?
In the plasma NOT at neuromuscular junction
NOTE: It is also found at the liver (and other tissues) and at glial cells
What are the substrates of psuedocholinesterase?
Butylcholine
ACH
Succinylcholine
Procaine
Demecarium
ACHE inhibitor
Treats glaucoma
Ambenonium
ACHE inhibitor
Treats myastenia gravis
_____________ inhibition is not reversed by pralidoxime.
Carbaryl
Lis the organophosphate inhibitors of AcHE
- Tetraethylpyrophosphate
- Echotiophate
- Diisopropylflurophosphate
- Sarin
- Soman
- Tabun
- Malathion
- Parathion
What drug can be used for soman poisining?
Pyridostigmine
List AChE inhibitors used for Alzheimer’s Disease
Tacrine
Donepezil
Rivastigmine
Galantamine
True or false. Pralidoxime cannot cross the BBB.
True
NOTE: In high doses pralidoxime can inhibit AChE
Atropine is a _________ (competitive/noncompetitive) inhibitor.
Competitive
What are the antispasmodic muscarinic antagonists?
- Flavoxate-urinary bladder
- Oxybutynin-urinary bladder
- Tolterodine- Urinary bladder
- Fesoterodine
- Dicyclomine
- Oxyphencyclimine
NOTE: These drugs are antispasmodics for bladder, ureter, gi tract, and bile duct
Which drugs are useful in treating peptic ulcers?
Pirenzepine (M1 and M4)
Telenzepine (M1)
NOTE: These drugs act as muscarinic antagonists
_________ blocks M2 muscarinic and the NN nicotinic sites.
Gallamine
