Pathogenesis of Bacterial Diseases

Question 1

Type III secretions

Answer 1

Yersinia

E.coli

Salmonella

P.aeruginosa

Chlamydia

Question 2

LPS is the major viralence factor in septic shock. What is the mechanism?

Answer 2

LPS activates macrophages which release TNF-a, IL-1 and IL-6. Leads to tissue damage. Daamge to the endothelium from brady kinin- induced vasodilation leads to shock. Coagulation (DIC) is mediated through activation of the hageman factor.

Question 3

Shiga-like toxin

Answer 3

Veratoxin

Question 4

Only gram positive bacteria with an endoxin

Answer 4

Listeria