Wound Healing Mediators

Question 0

What is the role of FGF?

Answer 0

Stimulates all aspects of angiogenesis

Question 1

What is the role of PDGF?
Secreted by…..?
Induces …..?
Stimulates…..?

Answer 1

Secreted by activated platelet and macrophages
Induces vascular remodeling and smooth muscle cell migration
Stimulates fibroblast growth for collagen synthesis

Question 2

What is the role of EGF?

Answer 2

Stimulates cell growth via tyrosine kinase (EGFR expressed by ERBB2)

Question 3

What is the role of TGF beta?

Answer 3

Angiogenesis
Fibrosis
Cell cycle arrest

Question 4

What is the role of mettaloproteinases?

Answer 4

Tissue remodelling

Question 5

What are the mediators in inflammatory phase?

Answer 5

Plt
Neutrophils
Macrophages

Question 6

What are the mediators involved in proliferative phase of wound healing?

Answer 6

Fibroblasts
Myofibroblasts
Endothelial cells
Keratinocytes
Macrophages

Question 7

What is the mediator involved in remodeling?

Answer 7

Fibroblasts

Question 8

What is the mediator involved in wound contraction?

Answer 8

Myofibroblasts