Tumor Suppressor Genes

Question 0

What is the neoplasm associated with gene BRCA 1 & BRCA 2

and its product?

Answer 0

Breast ca
Ovarian ca
DNA repair protein

Question 1

What is the neoplasm associated with gene APC

and its product?

Answer 1

Colorectal ca (associated with FAP)

Question 2

What is the neoplasm associated with gene CPD4/SMAD4?

Answer 2

Pancreatic ca

Question 3

What is the neoplasm associated with gene DCC?

Answer 3

Colon cancer

Question 4

What is the neoplasm associated with gene MEN1?

Answer 4

MEN type 1

Question 5

What is the neoplasm associated with gene NF1

and its product?

Answer 5

Neurofibromatosis type 1

RAS GTPase activating protein (neurofibromin)

Question 6

What is the neoplasm associated with gene NF2

and its product?

Answer 6

NeuroFibromatosis type 2

Merlin (schwannomin) protein

Question 7

What is the neoplasm associated with gene p16

and its product?

Answer 7

Melanoma

Cyclin-dependent kinase inhibitor 2A

Question 8

What is the neoplasm associated with gene p53

and its product?

Answer 8

Most human cancers
Li-Fraumeni syndrome
Transcription factor for p21, blocks G1==>S phase

Question 9

What is the neoplasm associated with gene PTEN?

Answer 9

Breast ca
Prostate ca
Endometrial ca

Question 10

What is the neoplasm associated with gene Rb

and its product?

Answer 10

Retinoblastoma
Osteosarcoma
Inhibit E2F, blocks G1==>S phase

Question 11

What is the neoplasm associated with gene TSC1

and its product?

Answer 11

Tuberous Sclerosis

Hamartin Protein

Question 12

What is the neoplasm associated with gene TSC2

and its product?

Answer 12

Tuberous Sclerosis

Tuberin protein

Question 13

What is the neoplasm associated with gene VHL

and its product?

Answer 13

Von Hippel-Lindau Dx

Inhibits hypoxia inducible factor 1a

Question 14

What is the neoplasm associated with gene WT 1&2

and its product?

Answer 14

Wilms Tumor (nephroblastoma)