Wound Healing Flashcards
1
Q
What are the goals of wound healing
A
- minimize the spread of tissue damage
- control infection
- remove dead tissue
- regeneration of the injured tissue to its normal functioning state
2
Q
Factors affecting wound healing
A
- oxygen
- moisture
- nutrition
- infection
3
Q
Goals fo inflammation phase
A
- limit the extent of tissue damage
- limit the spread of infection
- remove necrotic tissue, debris, & pathogens
4
Q
What does the wound look like during inflammation phase and its timing
A
- wound will look fresh, new, swollen, pink, & blood on the surface
-timing is from injury to 10 days
5
Q
What happens during the inflammation phase
A
- coagulation & temporary decrease blood flow
- necrosis
- decrease spread of pathogens
- oxygen delivery
- set the stage & signal
6
Q
What are the goals of proliferation and its timing
A
- rebuilding structure & framework of the wound
- timing is from day 3 to day 20
7
Q
What happens during the proliferation phase
A
- new tissue from fibroblasts create collagen
- re-epithelialization &/or contraction
- angiogenesis
- granulation tissue
- epithelial cells creates type III collagen
- scar weak
8
Q
Goals and timing of maturation/remodeling phase
A
-obtain complete wound healing & strength
- timing is from day 9 to 2 years
9
Q
What happens during maturation/remodeling phase
A
- epithelial cells continue to form type 1 collagen
- granulation tissue is replaced by less vascular tissue
- scar formation
10
Q
Describe primary intention
A
- surgical closure of wound
- stages of healing pass through on a similar scale
11
Q
Define dehiscence
A
- primary closure re-opens
12
Q
Describe secondary intention
A
- wound heals on its own
- tissue migrates, pulls to close, no new tissue formed
- disfiguring scars & impaired function
13
Q
Describe tertiary intention
A
- delayed primary intention
- healing begins with secondary then closed by primary
- delay generally due to presence of infection
14
Q
Role of oxygen in wound healing
A
- O2 is delivered to the wound through the blood
- O2 supports collagen deposition, angiogenesis, & granulation
- decreased O2 increases likelihood of infection
15
Q
What can limit perfusion
A
- edema
- necrosis
- vasoconstriction
