Women's Health-Gyn Flashcards
Follicular Phase =
aka Proliferative
Days 1-14 of cycle
**Estrogen predominant
Luteal Phase =
aka Secretory
Occurs after ovulation (aka after day 14)
**Progesterone predominant
-made by corpus luteum
When is the only time you do PAP before the age of 21?
When you are trying to rule out cervical causes of abnormal bleeding. IE: when there is post-coital bleeding
What is menorrhagia and what are ddx
-Heavy menstrual bleeding DDx: -Leiomyomas (not painful) -Adenomyosis (Painful) -Bleeding disorder -hyperplasia/carcinoma
Ddx of intermenstrual bleeding
- endometrial polyps
- unscheduled bleeding w/ contraceptive use
- endometrial hyperplasia or carcinoma
- infection (pain, discharge)
Irregular bleeding ddx
- *typically these women are not ovulating**
- ovulatory dysfunction
- common at extremes of repro age
- endocrine disorders (thyroid, PCOS)
Indications for endometrial biopsy
- post-menopausal (ie: any bleeding after menopause)
- age >45
- obesity (endogenous unopposed estrogen)
- diabetes (increased risk of endometrial cancer)
- break through bleeding on HT
- infertility
- family history of endometrial or colon cancer
Treatment of Abnormal uterine bleeding
- NSAIDs (naproxyn, ibuprofen) start 1 day before menses
- Hormonal manipulation (OCPS, progestin IUD)
- Endometrial ablation
- Hysterectomy
- Acute bleeding
What increases risk of endometrial cancer?
Unopposed estrogen
-RF: age, obesity, nulliparity, late menopause, tamoxifen, PCOS, DM, HTN, genetics (lynch and BRCA genes)
Most common type of endometrial cancer
-atypical glandular cells on cytology = Adenocarcinoma
What is primary amenorrhea?
- lack of menarche by age 16
- no evidence of pubertal onset by 13
- lack of menstruation w/in 2 years of onset of breast development
What is Sheehan Syndrome
-Pituitary infarct from post-pregnancy hemorrhage
Ex: Post partum woman breast feeding can’t make milk anymore
What labs to order to work-up secondary amenorrhea?
- HCG
- TSH
- Prolactin
- FSH
- Progesterone challenge
Secondary Amenorrhea w/ Prolactin >200
-Pituitary adenoma (check MRI/CT of sella)
Secondary Amenorrhea w/ Prolactin <200
-Medications (antipsychotics, lithium, anticonvulsants)
Secondary Amenorrhea w/ high FSH
Ovarian failure
Secondary Amenorrhea w/ low or normal FSH
Hypothlamic pituitary ovarian abnormality
What does progesterone challenge do?
Checks to see if pt is ovulating
-if she does bleed = everything is functioning just not ovulating
Primary Dysmenorrhea
begins soon after menarche
-non-pathologic
Tx: NSAIDs, OCPs
Secondary Dysmenorrhea
new onset in an older woman
-organic cause
Most common cause of secondary dysmenorrhea =
#1 = Endometriosis other = cervical stenosis
Presentation of endometriosis
-Pain PRECEDES and lasts through menses
-dysparenia
-infertility
-pelvic pain
-abnormal bleeding
Dx via laparoscopy
Tx of Endometriosis
ABlation, excision especially if they want to conceive
-Meds = ocps, nsaids, progesterone only, gnrh agonists (lupron, danocrine)
Tx of PMS
SSRIs
(reg exercise, avoid sugar and Etoh, NSAIDS)
other = spironolactone
Risk factors for cervical cancer
- early age of first coitus
- multiple sexual partners
- HPV 16, 18, 31, 33, 35
- personal hx of cervical dysplasia
- immunocomprised
- smoking (more difficult for immune sys to clear infection)
PAP Screen criteria
- age 21 regardless of age of onset of sexual intercourse
- 21-29: screen w/ cytology alone every 3yrs HPV test not recommended
- 30-65: screen w/ cytology and HPV testing every 5yrs (or cytology alone q 3yrs)
- > 65: discontinue screen if 2neg paps in past 10yrs and no hx of CIN2+ w/in the last 20yrs
About Follicular Cysts
Failure of the fluid in an incompletely developed follicle to be reabsorbed
NORMAL usually found incidentally on US
-20-25mm in size, clear fluid filled cyst
-usually asymptomatic
Tx: self-limited
About Corpus Luteum Cysts
Normal after ovulation
-may or may not be painful
-Typical in 1st trimester of pregnancy
Tx: self-limited
About Endometriomas
Associated w/ endometriosis aka chocolate cyst -benign -palpable mass on ovary -may or may not be painful Dx & Tx: US and aspiration
About Dermoids
Benign germ cell tumor -usually in young women -asymp finding on bimanual exam -CALCIFICATION on US/X-ray Tx: remove to avoid torsion or bleeding
Ovarian Torsion presentation and Tx
Most commonly caused by DERMOIDs
-sudden severe pelvic pain
US w/ doppler to look for blood flow
-surgery is necessary ASAP to preserve ovarian function
What is Stein-Leventhal Syndrome
aka PCOS
- Hyperandrogenism
- Insulin Resistance
- Anovulation
Clinical Presentation of PCOS
- Infertility
- Chronic Menstrual Irreg (oligomen, endometrial cancer)
- Hyperangdrogenism (acne, hirsuit, male pattern baldness)
- Insulin Resistance (central adip, acanthosis, DM2, CVD)
Lab Values in PCOS
-Estradiol = normal
LH/FSH 3:1
Free Testosterone >50
Insulin Resistance
Large cystic ovaries on US and physical exam
Tx of PCOS
Metformin = tx of choice for insulin resistance
- obesity = lifestyle changes
- Endometrial protection = OCPs
- Ovulation induction = weight loss, pharmacotherpay
- Ovulation induction = weight loss, clomiphene
- Dyslipidemia = weight loss, exercise, statins
RF for ovarian cancer
- Age (median = 60)
- First degree relative
- genetic synd
- nulliparity
- high fat diet/obesity
OCP use = protective
Screening tests for Ovarian Cancer
Screen those w/ 1st degree relative hx
- Pelvic exam
- CA125 (>35 is abnormal)alot of things w/ this
- Transvaginal US
Where is the first place ovarian cancer spreads
Omentum
What causes vagina and vulva cancer?
30-50% = HPV
Diagnosed on biopsy
Normal Vaginal pH
<4.5
About BV
Ph >4.5
-positive whiff test
-clue cells
Tx: Metronidazole 500mg BIDx 7 days
About Candida Vagintiits
RF: abx, pregnancy, OCP use consider DM screen in recurrent
-KOH = hyphae
Tx: Conazole creams or fluconazole 150mg PO x 1
About Trich
Caused by t. vaginalis
-pH > 6.0
-copious, frothy discharge
-punctate erythem vagin and cervix “strawberry”
Tx: Metronidzole 2g X 1 or 250-500 mg TID/BID x 7 days
treat partner and also test for other STDs
How to screen for chlamydia
-all sexually active women 25 and younger and other asymp women at increased risk
NAAT-Genprobe intracervical swab
LCT/PCR in urine
Tx: Azithromycin 1gram once or Doxycycline 100mg BID
Prsentation of PID
pelvic pain cervical motion tenderness dysparenia symp present around the time of menses FEVER
Labs in PID
elevated ESR, SBC
GC/chlamyd
hCG
Tx of PID
Hospitalize for high risk
Outpatient = ceftriaxone + doxy + metronidazole
PID Sequelae
- chronic pelvic pain
- dysparenia
- infertility
- ectopic pregnancy
Most reliable birth control method?
Mirena/Skyla IUD > Paraguard > Nexplanon
Depo Negatives
- 6% failure rate
- weight gain, menstrual irreg, depression, BB: lowers bone density, fertility delay
Progesterone only mini pill indications
tx of choice for breastfeeding women
Progesterone only mini pill contraindications
DVT
Liver Dz
Breast cancer
Advantages of combo hormonal therapies
- reduce risk of endometrial and ovarian cancer
- decrease dysmenorrhea
- improves acne
Disadvantages of combo hormonal therapies
- pills must be taken daily
- no protection from STIs
- CVD: thromboembolism, stroke, MI
Contraindications to combo hormonal therapies
- DVT/PE, CVA, CAD, Afib
- severe HTN or vascular/heart disease
- Migraine w/ Aura
- 35 years or older and smoker (>15 cig/day)
- Breast cancer
- complicated DM
- *Competes w/ seziure meds
- liver dz
- gall bladder dz
- lower efficacy in obese ts
What counts as infertility?
35 yrs who fail to conceive after 6 mo
Menopause is defined as
12mo of amenorrhea
How do you dx menopause
Check FSH and LH
FSH >30-40 (FSHincreases a lot; LH is low)
Presenting complaints of menopause
- vasomotor symp
- vaginal atrophy
- depressive symp, insomnia, irritability, lack of concentration
Hormonal replacement for menopause
Estrogen only = no uterus
Estrogen and Progesterone = if uterine intact
(lowest dose for shortest amount of time)
Benefits of HRT
- osteoporosis prevention
- lipid improvement
- may decrease onset of DM
- reduces colon cancer risk
Osteoporosis occurs where?
In trabelucar bone
T scores
1.0 to -1.0 = normal
-1.0 to -2.5 = osteopenia
< -2.5 = osteoporosis
Most common pathogen in mastitis
s. aureus
- most common reason for fever after immediate peurperium in nursing mothers
* if occurs in non-lactating women, consider cancer*
Causes of galactorrhea
- psychotropics
- cimetidine
- TCA
- OCP
- Depo
- CNS lesion (measure prolactin)
- Medical conditions (hypothyroidism)
Fibrocystic breast dz
-more painful just before menses and w/ consume of caffeine
Tx: avoid trauma, wear sports bra, NSAIDs, acetaminophen, OCPs, danocrine/lupron
Fibroadenoma
- *most common etiology of breast lump**
- young women
- benign solid mass
- typically painless or minimally painful
What do ALL palpable masses get?
- Mammogram
- US
- consider biopsy
RF for breast cancer
> 70% have no RF
- age
- family hx in 1st degree relative
- Modest increased risk = nulliparity, 1st preg after 30, menarche at 50, alcohol, obesity, and or high fat diet, tobacco use
Mammogram Schedule
- every 1-2 years starting at age 40
- every 1 year after age 50
- Women w/ BRCA1 or 2 may have annual or semiannual clinical breast exams along w/ annual mammography beginning at age 25-35.
Most common type of breast cancer
Infiltrating ductal carcinoma
most lethal = inflamm
Paget Dz of breast
- infiltrating intraductal carcinoma in the nipple and ducts of the nipple
- 1st symp = itching or burning of the nipple, therefore usually treated as eczema