Women's Health Drugs

Question 1

What is Endogenous Estrogen used for?

Answer 1

Menopausal hormone therapy (HT)

Female hypogonadism

Question 2

What is Endogenous Progestin used for?

Answer 2

Menopausal hormone therapy (HT)

Dysfunctional uterine bleeding or amenorrhea

Question 3

What two cancers can Endogenous Estrogen lead to?

Answer 3

Endometrial hyperplasia → endometrial Cancer

Breast Cancer

Question 4

What are Selective estrogen receptor modulators (SERMs) used for?

Answer 4

Menopause Hormone Therapy (HT)

Question 5

What 3 drugs are in the Selective estrogen receptor modulators (SERMs) class?

Answer 5

Tamoxifene
Raloxifene
Bazedoxifene

Question 6

What do Selective estrogen receptor modulators (SERMs) do?

Answer 6

Agonize estrogen receptors in some cells & block them in others

Question 7

3 adverse effects of Selective estrogen receptor modulators (SERMs)

Answer 7

Increases endometrial cancer risk

Increases hot flashes

Increases thromboembolism risk

Question 8

What do Combination oral contraceptives do??

Answer 8

Inhibit ovulation via FSH suppression (estrogen negative feedback)

The follicle cannot mature

Question 9

What is a “mini-pill”?

Answer 9

Progestin-only oral contraceptive

Question 10

What does a Progestin-only oral contraceptive do?

Answer 10

Changes cervical secretion

Question 11

What is the major for a Subdermal etonogestrel implant to be used?

Answer 11

irregular vaginal bleeding

Question 12

What does Depot medroxyprogesterone acetate do?

Answer 12

inhibition of FSH/LH secretion

Question 13

Which oral contraceptive has a black box warnign & why?

Answer 13

Depot medroxyprogesterone acetate because of bone loss risk

Question 14

How does a cooper IUD stop sperm from getting you prego?

Answer 14

Local foreign body rxn & chemical changes toxic to sperm

zaps those fuckers

Question 15

How does a Levonorgestrel IUD keep you from getting prego?

Answer 15

thickens cervical mucus, inhibit ovulation, alter the endometrium

Question 16

What is misoprostol used for?

Answer 16

Termination of early intrauterine pregnancy

Question 17

How does misoprostol work?

Answer 17

blockade of progesterone receptors → expulsion of conceptus

Question 18

What 3 drugs for follicular maturation?

Answer 18

Clomiphene, Menotropin & Follitropin

Question 19

Which two follicular maturation drugs require hCG to induce ovulation?

Answer 19

Menotropin & Follitropin

Question 20

What is hCG & choriogonadotropin alfa used for?

Answer 20

Facilitate ovulation

Question 21

What are the two big adverse effects of hCG & choriogonadotropin alfa?

Answer 21

Ovarian hyperstimulation syndrome

Ruptured of ovarian cyst

Question 22

What are the 5 tocolytic drug classes?

Answer 22

B2 agonists

Calcium channel blocker

COX inhibitors

Oxytocin receptor blockers

Magnesium sulfate

Question 23

What are tocolytic drugs used for?

Answer 23

Suppresses labor that has already started

Question 24

What B2 agonist drug is a tocolytic?

Answer 24

terbutaline

Question 25

How does terbutaline work?

Answer 25

Agonize B2 on uterine smooth muscle → decreased uterine contraction

Question 26

4 adverse effects of terbutaline

Answer 26

Pulmonary edema
Hypotension
Hyperglycemia
Tachycardia

Question 27

What COX inhibitor is

a tocolytic drug?

Answer 27

indomethacin

Question 28

how does indomethacin work?

Answer 28

Inhibits synthesis of prostaglandins → decreased uterine contractions via cAMP-mediated pathway

Question 29

What effect can indomethacin have on a fetus when given in high doses?

Answer 29

Can precipitate premature narrowing/closure of ductus arteriosus in high doses

Question 30

How Magnesium sulfate

work?

Answer 30

Inhibits ACh at the neuromuscular junction

Question 31

If a laboring mom is given Magnesium sulfate what should you be ready to do for the baby??

Answer 31

supporting the respiratory function of the newborn with mechanical ventilation

Question 32

What is Hydroxyprofesterase caproate used for?

Answer 32

Prevent preterm labor

Question 33

What are the 2 drugs for cervical ripening?

Answer 33

Dinoprostone & Misoprostol

Question 34

What are 2 adverse effects of Dinoprostone & Misoprostol?

Answer 34

Tachysystole (high rate of uterine contractions)

Systemic absorption → N/V, diarrhea, fever

Question 35

What is Oxytocin (Pitocin) used for?

Answer 35

Stimulate uterine contractions

Increased force, frequency, & duration of contractions → receptors increase in number as labor progresses

Question 36

You should only give Oxytocin (Pitocin) if what 2 things are ready?

Answer 36

if fetal lungs are mature and if the cervix is ripened

Question 37

What are the 4 drugs used for Drugs for Postpartum Hemorrhage?

Answer 37

Oxytocin
Misoprostol
Hemabate
Methylergonovine (Methergen)

Question 38

What Postpartum Hemorrhage drug should you use with caution if patient has asthma?

Answer 38

Hemabate –> because of intense vasoconstriction

Question 39

What Postpartum Hemorrhage drug do you only use for emergencies?

Answer 39

Methylergonovine (Methergen)

Question 40

What Postpartum Hemorrhage drug is a big NO NO if Mom has HTN?

Answer 40

Methylergonovine (Methergen)

Question 41

What is Tranexamic acid (TXA) used for?

Answer 41

Menorrhagia –> decrease bleeding

Question 42

three absolute contraindications of combination oral contraceptives or hormone therapy.

Answer 42

• pregnancy
• history of stroke
• history of myocardial infarction

Question 43

5 absolute contraindications to oral contraceptives

Answer 43

1. Breast, endometrial CA
2. Acute liver disease
3. Uncontrolled HTN
4. Thrombosis: DVT, MI, CVA
5. Undiagnosed vaginal bleeding