Anticoagulation drugs Flashcards
What does heparin do?
Equal suppression of thrombin & factor Xa
Activate antithrombin
Major adverse effects of heparin
hemorrhage
Heparin-induced thrombocytopenia (HIT)
What does warfarin do?
Long term prevention of thrombosis
Decreases production of factors II, VII, IX, X which all depend on vitamin K
Adverse effects of warfarin
Hemorrhage
Can warfarin be given to prego ladies?
can cause Fetal hemorrhage & teratogenesis (contraindicated in pregnancy) Infant hemorrhage (crosses breastmilk)
4 types of Direct thrombin inhibitors
Dabigatran, Desirudin, Bivalrudin & Argatroban
how do Direct thrombin inhibitors work?
Binds (inhibits) thrombin that is bound to clots
Decreased conversion of fibrinogen to fibrin
Decreased activation of factor XIII
End result = decreased conversion of soluble to insoluble fibrin
what drug is under Direct factor Xa inhibitors class?
Rivaroxaban
how do Direct factor Xa inhibitors work?
Selective binding (& inhibition) of factor Xa
Decreased production of thrombin
Inhibition of fibrin mesh formation
Direct factor Xa inhibitors work affect on prego women
Maternal hemorrhage
DO NOT GIVE
3 TYPES of Thrombolytics
Alteplase, Reteplase & Tenecteplase
what do Thrombolytics do?
Remove thrombi that have ALREADY formed
Binds plasminogen = active complex
Converts other plasminogen to plasmin
Plasmin digests fibrin meshwork & degrades clotting factors
What is faster: Heparin or Warfarin?
Heparin !!
When on Warfarin, what kind of things should you avoid including in your diet?
things with vitamin K!
Leafy greens, veggies, mayo
What drug interfers with the second step of platelet formation
Heparin
