Women's Health Flashcards
Hormone that inhibits FSH production
Inhibin
Hormone that stimulates anterior pituitary to produce and release LH and FSH
GnRH
Function of FSH
Function of LH
FSH:
- Follicle development
- Oestrogen production
- Inhibin B
LH:
- Ovulation
- Corpus Luteum Maintenance
- Progesterone production
Which hormone is synthesised from cholesterol in steroidogenic tissues such as the adrenal gland, gonads, and brain?
Pregnenolone
describes ‘oestrobolome’?
A collection of microbes capable of metabolising oestrogens
What is the most common and prominent mediator in the majority of PCOS cases?
Insulin resistance
What neurotransmitter is thought to be implicated in the pathogenesis of PMS and PMS-D?
Serotonin
Complete the statement: “High _____________ drives inflammation and angiogenesis, and hence endometriosis proliferation”
histamine
Laura is concerned about vaginal dryness as she enters menopause. Which herbal reproductive tonic and adaptogen might you recommend?
Shatavari
Carol has been diagnosed with endometriosis. Give 3 elements of a nutritional therapy approach?
a.
Promote optimal transit time and optimal intestinal microflora
b.
Normalise the immune response
c.
Optimise liver function
Which vitamin helps regulate aldosterone, and may reduce fluid retention in PMS?
B6
Phytoestrogens are plant-derived dietary compounds with structural similarity to what female sex hormone?
17-β-oestradiol (E2)
How does chronic stress contribute to oestrogen dominance?
It downregulates LH and FSH
What hormone levels are often raised in stress and PMS and what symptoms is it associated with?
Prolactin
- Breast pain
- Vaginal dryness
- Long or irregular cycles
3 things testosterone is downregulated by
2 things testosterone is upregulated by
Downregulated by
1. Nettle
2. Saw Palmetto
3. Lycopene
4. Green tea
Upregulated by
1. Insulin
2. Obesity
3. Inflammation
- What can cause increased conversion of 4-OH-E to quinones?
- What are the health implications of this?
- Poor methylation
- Quinones can increase oxidative damage to DNA and increase cancer risk
- Where is sex hormone binding globulin (SHBG) synthesised?
- What is the function of SHBG?
- In the liver
- Transports sex hormones in blood (sex hormones are not water soluble)
Why are astringent herbs useful to clients with fibroids?
They help to constrict blood vessels and control blood flow
What is the daily amount of evening primrose oil recommended to support fibrocystic breasts?
1000 mg 3 x a day
Methylation can be increased by supplementing what vitamins?
B12
Folate
B6
What is the name of exogenous agents that interfere with the production, release, transport, metabolism, binding, action or elimination of bodily hormones?
Endocrine disrupting chemicals
Fatima is being investigated for PCOS, list 4 markers you would expect to see on her results if she has PCOS.
- Elevated serum testosterone with DHT (because of reduced SHBG due to I.R.)
- Raised LH (LH hypersecretion)
- Low FSH
- Elevated serum prolactin
- Elevated HbA1c
- Raised fasting glucose
- Low sex hormone binding globulin (SHBG)
