Wk 4 Substance Use Disorder

Question 1

Rewarding effect from drugs from large surges of

Answer 1

dopamine

Question 2

Drugs mimic the regular response of dopamine but

Answer 2

greatly exceeds it

Question 3

Dopamine surges disrupt

Answer 3

regular dopamine pathways (receptor down regulation)

Question 4

Addiction is associated with deficits in the

Answer 4

prefrontal cortex

Question 5

In drug addiction, dopamine transporters are

Answer 5

diminished

Question 6

Loss of dopamine transporters can

Answer 6

be reversed with time

Question 7

Risk factors for substance abuse disorder

Answer 7

Primarily environmental: aggressive behavior in childhood, poor social skills, lack of parental supervision, early drug experimentation, availability of drugs at kid’s school

Question 8

Protective factos for substance abuse disorder

Answer 8

Good self control, parental monitoring and support, positive relationships, getting good grades, anti drug policies at schools

Question 9

Some people are less likely to abuse drugs because they do not get the..

Answer 9

dopamine surges when abusing drugs

Question 10

5 types of therapy for substance abuse disorder

Answer 10

CBT, contingency management/positive reinforcement, motivation enhancement therapy, family therapy, 12 step facilitation programs

Question 11

Common medications used to treat opioid abuse

Answer 11

methadone, bruphenorpine, naltrexone (ER), lofexidine

Question 12

Common medications used to treat nicotine abuse

Answer 12

NRT, bupropion, varenicline

Question 13

Common medications to treat alcohol abuse

Answer 13

naltrexone, disulfiram, acamprosate

Question 14

Crucial first step in treatment of drug abuse

Answer 14

medically assisted detoxification

Question 15

Drug abuse treatment need to be tested for

Answer 15

HIV, Hep B and C, TB, endocarditis

Question 16

Suboxone is a combination of

Answer 16

Naloxone and buprenorphine

Question 17

If someone who takes opioids stops cold turkey they will experience withdrawal symptoms in

Answer 17

12-24 hours from last dose

Question 18

Opioid withdrawal typically lasts

Answer 18

5-10 days

Question 19

Opioid withdrawal peaks at

Answer 19

72 hours (day 3)

Question 20

Symptoms of withdrawal opioid

Answer 20

flu-like, goose bumps, depression, intense cravings, anxiety

Question 21

How to treat opioid withdrawal

Answer 21

supportive treatment

Question 22

At 2 weeks past opioid withdrawal, physical symptoms have lessened but

Answer 22

there are psychological and emotional symptoms

Question 23

At 1 month after opioid withdrawal

Answer 23

depression and cravings still linger

Question 24

Benzo and alcohol have the same withdrawal symptoms… why?

Answer 24

They both work on GABA receptors

Question 25

Methadone will not help

Answer 25

someone addicted to alcohol or bentos

Question 26

Difference between benzo/alcohol withdrawal versus opioid withdrawal

Answer 26

Benzo and alcohol withdrawal can kill a person, while opioid withdrawal cannot

Question 27

Signs and symptoms of withdrawal from benzos and alcohol

Answer 27

sleep disturbances, irritability, nausea, increased tension, weight loss, panic attacks, perceptual changes, sweating

Question 28

Dangerous symptoms of alcohol and benzo withdrawal

Answer 28

seizures, hallucinations, delirium tremors, Wernicke’s encephalopathy

Question 29

Delirium tremens

Answer 29

hallucination, disorientation, tachycardia, hypertension, fever, agitation, diaphoresis

Question 30

Benzo withdrawal starts at

Answer 30

6-12 hours

Question 31

Benzo withdrawal peaks at

Answer 31

2 WEEKS!

Question 32

Alcohol withdrawal starts at

Answer 32

8 hours

Question 33

Alcohol withdrawal peaks at

Answer 33

1-3 days and will taper off at about a week

Question 34

For alcohol and benzos we will

Answer 34

taper them off, to prevent the dangerous side effects

Question 35

Those with alcohol withdrawal require a

Answer 35

Vitamin b1 (thiamine) supplement

Question 36

Why do alcoholics need a b1 supplement?

Answer 36

Long term alcohol use causes stomach inflammation inhibiting the vitamin b1 absorption