Why Quitting is Difficult Flashcards
What is nicotine?
An alkaloid that is contained in the leaves of plants
Nicotine is distributed quickly thorugh the bloodstream and crosses the…
blood-brain barrier
Nicotine reaches the brain within ____ seconds with inhalation
8-20
Elimination half-life of nicotine is around __ hours
2
Nicotine is metabolized in the…
liver
What is the effect of nicotine?
- Stimulates adrenal glands
- Increased heart rate, breathing activity, and blood pressure
- Pancreas produces less insulin - causing increased blood sugar
- Dopamine released
- Acetylcholine and Norepinephrine released – concentration and memory
- Increased levels of beta-endorphin – reducing anxiety
What does increased levels of beta-endorphin do?
reduces anxiety
The amount of nicotine absorbed by the body from smoking depends on:
- type of tobacco
- whether the smoke is inhaled
- whether a filter is used
Amount released into the body tends to be much greater in ___________ tobacco
smokeless
Research indicates development of brain continues to occur until the age of ____
25
Nicotine changes the way ________ are formed
synapses
- can harm the parts of the brain that control attention and learning
The nicotine in e-cigarettes and other tobacco products can also prime the adolescent brain for…
addiction to other drugs such as cocaine
How does nicotine impact youth/young adults?
- Depression
- Anxiety
- Mood disorders
- Addiction
- Difficulty paying attention
- Reduced impulse control
Why does the nicotine dependence cycle happen?
use of nicotine -> stimulates dopamine release -> causes pleasurable feeling -> repeated use of nicotine -> tolerance develops -> cycle starts over
Why does nicotine tolerance develop?
Body will create more nicotine receptor sites over time
What is the physiological part of tobacco dependence?
The addiction to nicotine
Use medications for cessation as the treatment
What is the behavioral part of tobacco dependence?
Start a behavior change program
_________ should address the physiological and the behavioral aspects of dependence
Treatment
What are the symptoms of withdrawal?
- Dizziness; 1-2 days
- Cravings for tobacco; first 2-3 days
- Chest tightness; few days
- Cough, dry throat; few days
- Difficulty concentrating; few days
- Insomnia; 1 week
- Constipation, stomach pain; 1-2 weeks
- Depressed mood, irritable; 1-4 weeks
- Fatigue; 2-4 weeks
- Hunger; several weeks
What are the benefits from quitting smoking for 20 minutes?
Blood pressure returns to normal
What are the benefits from quitting smoking for 8 hours?
Normal oxygen blood level
What are the benefits from quitting smoking for 24 hours?
Carbon monoxide eliminated from lungs – start to clear mucus
What are the benefits from quitting smoking for 48 hours?
- Nicotine is eliminated
- Smell and taste improve
What are the benefits from quitting smoking for 3 days?
- Lung capacity begins to improve
- Breathing become easier
What are the benefits from quitting smoking for 2-12 months?
Circulation improves
What are the benefits from quitting smoking for 5 years?
Risk of lung cancer decreases
What are the benefits from quitting smoking for 10-15 years?
Reduced risk of other cancers
Benefits of quitting smokeless tobacco…
Decreased risk for:
* oral, head and neck cancer
* tooth decay
* progression of gum recession
* high cholesterol
* high blood pressure
* heart attack or stroke
What are some of the assistance in cessation products?
- nicotine transdermal patches (23%)
- nicotine gum and lozenges (27%)
- non-nicotine vareniciline (22-24%)
- non-nicotine zyban (16%)
What do we ask someone who is smoking?
- ASK about tobacco USE
- ADVISE tobacco users to QUIT
- ASSESS READINESS to make a quit attempt
- ASSIST with the QUIT ATTEMPT
- ARRANGE FOLLOW-UP care
What do you ask about tobacco use?
◼ “Do you ever smoke or use any type of tobacco?”
◼ “Do you use any form of e-cigarette or vaping device?”
◼ “Do you, or does someone in your household smoke?”
If yes to these quesions…ask about the amount per day and for how long they have been smoking (access risk for lung cancer)
What advice can you give to tobacco users to quit?
◼ “I realize that quitting is difficult. I am happy to work with you to design a specialized treatment plan for cessation when you are ready.”
◼ Best results if you can personalize this and be open, non-judgmental
clear, strong, personalized
What are the options for assisting with the quit attempt?
◼ Not ready to quit: provide motivation
◼ Ready to quit: design a treatment plan
◼ Recently quit: relapse prevention
What are the transtheoretical change model/stages of change?
What is the estimated quit rate for 0-1 sessions of follow-up care?
12.4%
What is the estimated quit rate for 2-3 sessions of follow-up care?
16.3%
What is the estimated quit rate for 4-8 sessions of follow-up care?
20.9%
What is the estimated quit rate for more than 8 sessions of follow-up care?
24.7%
What is the pre-contemplation stage of the transtheoretical change method?
No intention to change
What is the contemplation stage of the transtheoretical change method?
Aware problem exists but no commitment to action
What is the preparation stage of the transtheoretical change method?
Intent on taking action to address the problem
What is the action stage of the transtheoretical change method?
Active modification of behavior
What is the maintenance stage of the transtheoretical change method?
Sustained change, new behavior replaces old
What is the termination stage of the transtheoretical change method?
Not falling back into previous behavior
What is the relapse stage of the transtheoretical change method?
Falling back into previous behavior patterns
What are the cessation options?
- Cold Turkey (no additional help)
- Nicotine Replacement Therapy (NRT’s)*
- Medications*
- Behavioral Therapy
- Combination Therapy
- Hypnotherapy – Reveri app
- Acupuncture
- Yoga, meditation
- Herbs
T/F: all tobacco users can benefit from pharmacotherapy
Yes (check patient history)
Check with a physician if the patient has… before starting pharmacotherapy
- Hypothyroidism
- Insulin-dependent diabetes
- Active peptic ulcer
- Anti-depressant medications
Bupropion SR (zyban) has _____ mg sustained release tablet
150
When should you begin taking bupropion SR (zyban)?
- Begin taking 1 week prior to quitting
- Double dose after 3 days
What are the advantages of bupropion SR (zyban)?
- Easy to use
- Can be used with Nicotine Replacement Therapy (NRT)
What are the adverse effects of bupropion SR (zyban)?
- Insomnia
- dry mouth
- nervousness/difficulty concentrating
- rash
- constipation
- seizures
How do you write a zyban (bupropion SR) prescription?
Rx: Zyban Starter Pack
Disp: 1 (one) package
Sig: Take as directed
0 refills
Rx: Zyban Maintenance Pack
Disp: 1 (one) package
Sig: Take as directed
2 refills
Varenicline comes in what mg tablets?
0.5 mg and 1.0 mg tablet
How should your patient take the Varenicline?
- Days 1-3: take one 0.5 mg tablet in the AM
- Days 4-7: take 0.5 mg tablet twice daily
- Weeks 2-12: take 1.0 mg tablet twice daily
What are the advantages of Varenicline?
Easy to use and offers a new mechanism of action for patients who have failed with other agents
What are the adverse effects of Varenicline?
- Nausea, insomnia, vivid dreams, constipation, & vomiting
- Neuropsychiatric symptoms
— behavior changes
— agitation
— depressed mood
— suicidal ideation or behavior
Is varenicline approved for use with other Nicotine Replacement Therapy (NRT)?
NO
How do you write a prescription for Varenicline?
Varenicline Starting Month/Pack
Disp: 1 (one) package
Sig: Take as Directed
0 Refills
Varenicline Continuing Month/Pack
Disp: 1 (one) package
Sig: Take as Directed
2 refills
How many mg are the Gum (nicorette, zonnic)?
2 mg (smoke < 25 cig/day)
4 mg (smoke ≥ 25 cig/day)
How should your patient take the Gum (nicorette, zonnic)?
- Week 1-6: 1 piece every 1-2 hours
- Week 7-9: 1 piece every 2-4 hours
- Week 10-12: 1 piece every 4-8 hours
- Max of 24 pieces per day. No food or beverage 15 min before or during use
What are the advantages of Gum (nicorette, zonnic)?
May delay weight gain and satisfy oral cravings
What are the adverse effects of Gum (nicorette, zonnic)?
- Mouth/jaw soreness
- hiccups
- dyspepsia
How many mg are the lozenge (nicorette, zonnic)?
2 mg (smoke > 30 min after waking)
4 mg (smoke ≤ 30 min after waking)
How should your patient take the lozenge (nicorette, zonnic)?
- Week 1-6: 1 lozenge every 1-2 hours
- Week 7-9: 1 lozenge every 2-4 hours
- Week 10-12: 1 lozenge every 4-8 hours
- Max. of 20 lozenges/day. No food or beverage 15 min. before or during use. Do not chew or swallow lozenge
What are the advantages of lozenge (nicorette, zonnic)?
May delay weight gain and satisfy oral cravings
What are the adverse effects of lozenge (nicorette, zonnic)?
- Nausea
- hiccups
- -cough
- heartburn
- headache
- insomnia
How many mg are the transdermal patch (nicoderm CQ)?
7 mg, 14 mg, 21 mg (24-hour release)**
less than 10 cigarettes/day
- 14 mg/day for 6 weeks
- 7 mg/day for 2 weeks
more than 10 cigarettes/day
- 21 mg/day for 6 weeks
- 14 mg/day for 2 weeks
- 7 mg/day for 2 weeks
What are the advantages of the transdermal patch (nicoderm CQ)?
Provides consistent Nicotine for 24 hrs, easy to use
What are the adverse effects of the transdermal patch (nicoderm CQ)?
- Local skin reaction
- headache
- insomnia
- vivid dreams
How many mg are the nasal spray (nicotrol NS)?
0.5 mg metered spray per 50 mcL
How should your patient use nasal spray (nicotrol NS)?
- 1-2 doses per hour
— 8-40 doses/day
—Maximum 5 doses/hr - One dose = 2 sprays (1 per nostril)
What are the advantages of nasal spray (nicotrol NS)?
Patients can titrate therapy to help with withdrawal
What are the adverse effects of nasal spray (nicotrol NS)?
- Nasal/throat irritation
- rhinitis
- tearing
- sneezing
- headache
- cough
How many mg are the oral inhaler (nicotrol)?
10 mg cartridge – delivers 4 mg inhaled nicotine vapor
How should your patient use the oral inhaler (nicotrol)?
- 6-16 cartridges/day
- Begin with 1 cartridge every 1-2 hours
— Best effects with continuous puffing for 20 min.
What are the advantages of the oral inhaler (nicotrol)?
Patients can titrate amount to manage withdrawal and mimics hand-to-mouth ritual
What are the adverse effects of the oral inhaler (nicotrol)?
- Mouth/throat irritation
- cough
- headache
- rhinitis
- dyspepsia
UMKC has a ___________ Program that is free for patients wanting to participate
Tobacco Cessation