Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathology > White Blood Cell Quiz > Flashcards

White Blood Cell Quiz Flashcards

1
Q
  • Pro-lymphocytes (mitotically active) aggregate together forming proliferation centers
  • Smudge Celll
  • CD19, 20, 23, and 5 (T-cell marker)
  • Location: Blood and marrow
A

CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q
  • Pro-lymphocytes (mitotically active) aggregate together forming proliferation centers
  • Smudge Celll
  • CD19, 20, 23, and 5 (T-cell marker)
  • Location: Lymph nodes
A

SLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q
  • CD10, 18, 22, and TdT
  • Invade bone marrow
  • t(9;22) or (12;21)
A

Precursor B cell ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q
  • CD3, 7, and TdT
  • Thymic tumor
  • t(9;22) or (12;21)
A

Pre T cell ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q
  • Nodular pattern of infiltration of tissue
  • sIg, CD 19, 20, and CD79a (CD5 is not expressed)
  • Stain for bcl-2 is (+)
  • T(14;18)
A

Follicular Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q
  • CD19, 20, 22, 79a, sIg
  • Cells overexpress bcl-6
  • Large cells
A

Diffuse Large B cell Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q
  • CD10, 19, 20, 22, 79a, sIg, and bcl-6
  • Translocation involves c-myc on chromosome 8
  • Marophages with ingested debris
  • Small cells
A

Burkitt Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q
  • Mott cell (perinuclear clearning)
  • cIg (+)
  • Punched out bone lesions
A

Multiple Myeloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
  • CD19, 20, 22, 79a, surface IgM
  • NOT CD5 or CD23 (distinguishes from B-CLL)
  • Intranuclear inclusion, IgM
  • Secretes M protein
  • NO L-chains
A

Lymphoplasmacytic Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q
  • Resemble normal B cells
  • CD5, 19, 20, 22 and sIg (IgM)
  • NO CD10 or 23
  • Over expression of cyclin D1
  • Painless lymphadenopathy
A

Mantle Cell Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q
  • CD19, 20, 22, 79a, sIgM
  • Associated with H. pylori infxn
A

Extranodal Marginal Cell Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q
  • CD19, 20, 22, 79a, sIgM
  • Replaces white pulp germinal centers
A

Splenic Marginal cell lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q
  • Thin membrane protrusions (looks like hair)
  • CD103
  • Marrow fibrosis
  • Massive splenomegaly and pancytopenia
A

Hairy Cell Leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q
  • CD4, 30
  • Anaplastic lymphoma kinase
  • Infiltration of dermis and generalized lymphadenopathy
A

Anaplastic Large Cell Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q
  • HTLV-1 Provirus Positive
  • CD2, 3, 5
  • Hyperlobated nuclei
  • Bone and cutaneous lesions
A

Adult T cell Leukemia / Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q
  • CD4, 2, 3, 45RO, 5
  • Cells form bands thru tissue
  • Symptoms
    • Inflammatory preneoplastic phase: like eczema
    • Plaque phase
    • Tumor phase: with ulcerations
A

Mycosis Fungoides

17
Q
  • CD4, 2, 3, 45RO, 5
  • cell with cerebriform shaped nucleus
  • Erythroderma
  • Lymphadenopathy
A

Seazary Syndrome

18
Q
  • TCR, CD3, CD8
  • Lymphocytosis
  • Anemia
  • Neutropenia
A

T cell variant Large Granular Lymphocytic Leukemia

19
Q
  • CD56
  • B symptoms
  • Hepatosplenomegaly
  • Anemia / Thrombocytopenia
A

NK cell variant Large Granular Lymphocytic Leukemia

20
Q
  • CD2 and CD56
  • Associated with EBV
  • Invade small vessels
  • ischemic necrosis
  • Most commonly affects nose and sinuses
A

Extranodal NK / T cell Lymphoma

21
Q
  • HRS Lacunar cells
  • CD15+, CD30+, EBV-, CD20-
  • Bands of collagen divide tissue into nodules
A

Nodular Sclerosis Hodgkins Lymphoma

Presents in Stage 1 or 2

22
Q
  • Classic HRS and Mononuclear variants
  • CD15+, CD30+, EBV+
A

Mixed Cellular HL

Presents in stage 3 or 4

23
Q
  • Classic HRS cell and Mononuclear variants
  • CD15+, CD30+
  • 40% EBV+
  • Infiltrate mostly T cells
A

Lymphocyte Rich HL

24
Q
  • Hypocellular infiltrate
  • CD15+, CD30+, EBV+
  • Non-collagenous fibrosis
A

Lymphocyte Depletion HL

Presents in Stage 3 or 4

25
Q
  • Popcorn cell
  • CD20+
  • Able to produce Ig
  • Inguinal node involvement
  • Inflammatory infiltrate mostly B cells
A

Nodular Lymphocyte Predominant HL

Presents in stage 1 or 2

26
Q
  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with clear cytoplasm
A

AML, M1

27
Q
  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with fine, azurophilic peroxidase positive granules
A

AML, M2

28
Q
  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with Hypergranular, azurophilic peroxidase positive granules and Auer rods
A

AML, M3

29
Q
  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with basophilic granules in cytoplasm
A

AML, M4

30
Q
  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large, folded or lobulated nucleus
  • Peroxidase negative
  • Esterase positive
A

AML, M5

31
Q
  • Circulating neutrophils, metamyelocytes, and myelocytes
  • Marrow is ~100% cellular
  • bcr-abl fusion gene
A

CML

32
Q
  • Hypercellular bone marrow
  • erythrocytosis, granulocytosis, and thrombocytosis in periphery
  • Increased red cell mass and hematocrit
  • Low lvls of EPO
  • Erythromelalgia
A

Polycythemia Vera

33
Q
  • Thrombocytosis with giant platelets
  • Erythromelalgia
  • Characteristics of other myeloproliferative diseases are absent
A

Essential thrombocytosis

Must be diagnosed by excluding other diseases

34
Q
  • Marrow fibrosis
  • In marrow, megakaryocytes are large and clustered
  • Peripheral blood shows nucleated erythroid progenitors, granulocytic progenitors, and teardrop shaped RBCs
A

Primary Myelofibrosis

Marrow converted to bone late in disease

35
Q
  • Cells express CD1, S-100, HLA-DR
  • Birbeck granules with areas of dilation
A

Langerhans cell histiocytosis

36
Q

What is the Hand Schuller Christian triad?

A
  • In Langerhans Cell Histiocytosis
    • Diabetes insipidus
    • Exophthalmos
    • Involvement of calvaria

Pathology (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions