Female Reproductive System Flashcards
This cell type is characteristic of what type of infxn?

HSV
- Cell characteristics:
- Multinucleated giant cell
- eosinophilic inclusions
- Ground-glass nuclei
- Symptoms
- inguinal lymphadenopathy
- Red papule => vesicle => pustule => painful ulcer
- Dysuria / urinary retention

The picture respresents what type of infxn?

Molluscum contagiosum type II (Pox virus)
- Cell characteristics
- Large intracytoplasmic viral inclusions
- Gross appearance
- Pearly, dome - shaped papules with dimpled center
The cell type is characteristic of what type of infxn?

Trichomoniasis
- Organism: Trichomonas vaginalis
- Cell characteristics:
- flagellated protozoan
- Symptoms
- Strawberry cervix
- Vaginal discharge
- yellow-green / gray
- Copious
- Frothy
- Fishy odor

The histology below shows what type of infxn?

Gardnerella vaginalis = bacterial vaginosis
- Histo
- epithelial cells from PAP smear
- covered in organisms
- Symptoms
- Discharge
- Gray / white
- fishy odor
- not frothy like trichomonos
- Discharge
Mycoplasma infection of the endometrium has been shown to cause what complications?
- Infertility
- Preterm delivery
- Spontaneous abortion
- Chorioamnionitis
The histology below indicates what disease? What is the most likely infectious cause?

PID
- Cause:
- Chlamydia

What organisms cause PID?
- Gonococcus
- Chlamydia
- Enteric bacteria
- Strep
- Staph
- Clostridium perfringens
What is the progression of PID infxn (gonococcal)?
- Begins in Glands
- Bartholin, vestibular or periurethral glands
- Acute suppurative salpingitis
- may leak out of fimbriated end
- Salpingo-oophoritis
- fibria seal or become plastered against ovary
- abscess can form
- fibria seal or become plastered against ovary
- Pyosalpinx
- Hydrosalpinx (proteolysis of pus)
What is the progression of PID in non-gonococcal infxn?
- Ascend thru lymphatics and veins rather than mucosa
- Greater inflammatory response deep in tissue
- less exudate and mucosal involvement
- May spread to adjacent organs
What are the complications of PID?
- Peritonitis
- Intestinal obstruction from adhesion between bowel and pelvic organs
- Bacteremia
- Infertility
What is pictured below?

Bartholin cyst
The histology below shows what disease?

Lichen sclerosus
- Characteristic:
- Parchment-like skin
- Histo
- Epidermal thinning
- Hyperkeratosis of upper layers
- Basal degeneration

What is pictured below?

Squamous cell hyperplasia
(Lichen simplex chronicus)
- Key feature:
- No atypia
- Clinical feature
- pruritis
- Gray-white or red with white plaques
- Stenosis of vag opening not seen (as in lichen sclerosus)
The histology below is characteristic of what disease?

Condyloma acuminatum
- Infxn by HPV 6 and 11
- Histology
- koilocytes
- perinuclear clearing
Basaloid and Warty carcinomas
- Type of cancer
- Associated with infection by what?
- Gross appearance
- Microscopic appearance
- Type of cancer
- SCC of vulva
- Associated with infection by what?
- High risk HPV
- 16, 18, 31
- High risk HPV
- Gross Appearance
- White or pigmented plaques
- Microscopic appearance
- Basaloid: poorly-differentiated
- Warty: well-differentiated, koilocytic atypia

Keratinizing Squamous Cell Carcinoma
- Associated with what medical conditions?
- Gross appearance
- Microscopic appearance
- Cause

- Association
- long standing squamous cell hyperplasia
- Lichen sclerosis
- Gross appearance
- Nodules in background of inflammation
- Microscopic appearance
- atypia of basal layers
- keratin pearls
- Cause
- Association w/ p53 mutation

What are the most common locations of lymph node involvement in keratinized SCC of the vulva? Of other metastasis?
Nodes:
- Inguinal
- Pelvic
- Iliac
- Periaortic
Mets:
- Lung
- Liver
Papillary hidradenoma
- Origin
- Associated with infection by what?
- Gross appearance
- Microscopic appearance

- Origin
- apocrine sweat gland
- Associated with infection by what?
- Gross appearance
- dome shaped
- well circumscribed nodule
- Outcome:
- benign course

What disease is pictured?

Extramammary Pagets disease

What disease is pictured?

Malignant melanoma
Markers for Paget vs melanoma
- Paget
- Keratin 7 (+)
- PAS (+)
- mucopolysaccharide stain
- Melanoma
- S-100 (+)
- Lacks keratin and PAS staining
What disease process is pictured below?

Vaginal adenosis
- Histo
- Focal remnants of columnar, glandular epithelium of mullerian duct
- mucous-secreting epithelium (like endocervix) or
- tuboendometrial epithelium

What disease process is pictured below?

Vaginal adenocarcinoma
What disease process is pictured below?

- Histo
- Fibromyxomatous stroma
- Mucus - secreting endocervical glands
- Symptoms
- vaginal spotting or bleeding

















































































