Path of Thyroid and Spleen

Question 1

What cells predominate in the white pulp of the spleen?

Answer 1

Lymphocytes

B cells

Question 2

What cells predominate in the red pulp?

Answer 2

Mononuclear phagocytes

Question 3

What are the normal functions of the spleen?

Answer 3

• Filter blood
  
  • remove dead cells
• Immune function
• Site of extramedullary hematopoiesis
• Sequestration of blood elements

Question 4

Splenomegaly

• Symptoms
• Causes

Answer 4

• Symptoms
  
  • dragging or full sensation
    
    • Left Upper Quadrant
  • Discomfort after eating
• Causes
  
  • Infx
  • Portal HTN
  • Cancer

Question 5

Acute Splenitis

• Signs
• Path
• Cause

Answer 5

• Signs
  
  • Splenomegaly
• Path
  
  • Acute congestion of red pulp
• Cause
  
  • Blood borne infx

Question 6

What causes Congestive Splenomegaly?

Answer 6

• Chronic venous congestion
  
  • Most common: Cirrhosis of liver
    
    • Infx
    • Portal HTN
    • Cancer

Question 7

What is the origin of emboli causing splenic infarcts?

Answer 7

Heart

Question 8

What types of neoplasms occur in the spleen?

Answer 8

Myeloid and lymphoid

Question 9

Spontaneous Splenic Rupture is associated with what underlying conditions?

Answer 9

Underlying condition + minor trauma

Mono

Malaria

Cancer

Question 10

DiGeorge syndrome is associated with what thymic disorder?

Answer 10

Hypoplasia

Question 11

Myasthenia gravis is associated with what thymic disorder?

Answer 11

Hyperplasia

Question 12

What cell types are associated with the following types of thymomas?

• Benign
• Type I
• Type II

Answer 12

• Benign
  
  • Medullary or cortical epithelial cells
• Type I
  
  • Cortical epithelial cells
• Type II
  
  • Squamous cell carcinomas
    
    • express CD5
    • Pleomorphic nuclei