Whipple's disease

Question 1

Whipple’s disease is a rare multi-system disorder caused by

Answer 1

Tropheryma whippelii

Question 2

whole disease is more common in ?

Answer 2

HLA-B27 positive

Question 3

features of whipple disease ?

Answer 3

malabsorption: diarrhoea, weight loss

large-joint arthralgia - migratory

lymphadenopathy

skin: hyperpigmentation and photosensitivity

pleurisy, pericarditis

neurological symptoms (rare): ophthalmoplegia, dementia, seizures, ataxia, myoclonus

Question 4

Investigation of whipple disease ?

Answer 4

jejunal biopsy shows deposition of macrophages containing Periodic acid-Schiff (PAS) granules

Question 5

Management

Answer 5

oral co-trimoxazole