H. pylori Flashcards
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first line management of H pylori ?
PPI, amoxicillin and clarithromycin or
a PPI, amoxicillin and metronidazole
second line mx for H pylori
use a PPI, amoxicillin and either clarithromycin or metronidazole
whichever was not used for first-line treatment.
patients who have an inadequate response to second-line treatment, patients should be?
referred for upper GI endoscopy
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Helicobacter pylori test
Urea breath test
Rapid urease test (e.g. CLO test)
Serum antibody
Culture of gastric biopsy
Gastric biopsy
Stool antigen test
method of urea breath test ?
consume a drink containing carbon isotope 13 (13C) enriched urea
urea is broken down by H. pylori urease
after 30 mins patient exhale into a glass tube
mass spectrometry analysis calculates the amount of 13C CO2
urea breath test should not be performed ?
within 4 weeks of treatment with an antibacterial
or within 2 weeks of an antisecretory drug (e.g. a proton pump inhibitor)
urea test is most specifically used for ?
to check for H. pylori eradication
what remains positive after H pylori eradication
Serum antibody
Stool antigen test
sensitivity 90%, specificity 95%
before second-line treatment is considered what is suggested ?
recommends re-testing for H. pylori using urea breath test (for eradication)
he carbon-13 urea breath test is the most accurate method of re-testing for H. pylori
should be performed 4 weeks after the eradication therapy
before second-line treatment is considered what is suggested ?
recommends re-testing for H. pylori using urea breath test (for eradication)
he carbon-13 urea breath test is the most accurate method of re-testing for H. pylori
should be performed 4 weeks after the eradication therapy
