Hepatitis B Flashcards
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describe HBV structure ?
nucleocapsid
partially double stranded circular DNA with dna polymerase and reverse transcriptase = for replication
=HBcAG
between two - HBeAg
outer envelope of surface protein = HBs antigen
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how many genotypes of HBV is there ? and describe their geographic distribution
8 -A B C D E F G H
A, D = europe and USA
D = balkan peninsula and mediterranean 100 percent of bulgarian HBVD
D highly susceptible for development of mutations in “pre-core” region
giving Prevalence of HBeAg negative chronic hepatitis
Associated with poor results of interferon treatment
B, C = asia
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Hep B infection serology IN ACUTE hep
1) surface antigen (HBsAg) is the first marker to appear
+ HbEAg
2) IgM Anti HbCab + total anti HbC rising
3) The HbSAg drop
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IgM antiHbC drop in 6 months (total anti HbCAb persist)
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HbEAg drop
4) followed by increase in Anti -HbSab (SHOWS IMMUNITY)
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anti HbEAb
Hep B infection serology IN chronic hep
1) surface antigen (HBsAg) is the first marker to appear
+ anti HbEAg
2) IgM Anti HbCab + total anti HbC rising
3) No drop in HbSAg present for > 6 months
HbEag persist
Drop in IgM HbCAb after 6 months
4) No anti HbS ab formed
Anti HbEAb formed after years
which marker detonates previous (or current) infection
total anti HbCAg
Marker of HBV replication and infectivity
HbeAg
previous immunisation go Hep B?
anti-HBs positive, all others negative
