Week in Review 1

Question 1

what does osmotic diuresis lead to in the nephron

Answer 1

• increased rate of flow

Question 2

how does ADH contribute to the magnitude of the medullary osmotic gradient

Answer 2

• reabsorbs urea

Question 3

which nephron segment is responsible for the majority of ADH mediated water uptake

Answer 3

• cortical collecting duct

Question 4

impaired urinary concentration in Sickle cell disease driven by

what does it lead to

Answer 4

• loss of vasa recta

- polyuria and enuresis in children

Question 5

formula for fractional excretion

Answer 5

UV/PxGFR x 100

amount excreted/filtered load

U/P for substance X
________________
U/P for creatinine

Question 6

if the fractional excretion of something is less than 5%, what does that mean about the loss of something

Answer 6

• it is lost somewhere else besides the kidneys

Question 7

if the fractional excretion of something is greater than 5% what does that tell us about the lost

Answer 7

• it is lost by the kidneys

Question 8

creatinine clearance is basically equal to

Answer 8

• GFR