Renal Overview Flashcards

1
Q

the kidney is subject to regulation by

A
  • hormones

- autonomic nervous system

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2
Q

what does the interlobular artery feed into

A
  • afferent arteriole
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3
Q

what is the vasa recta

A
  • specialized peritubular capillaries
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4
Q

most renal blood flow occurs in the

A
  • cortex
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5
Q

components of the glomerulus

A
  • glomerular capillaries

- Bowman’s capsule

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6
Q

main purpose of Bowman’s capsule

A
  • filtration of plasma into Bowman’s space
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7
Q

role of proximal tubule

A
  • reabsorbs all glucose and amino acids, bicarb, ions, and water, and 50% of urea
  • secretes H+ and some drugs, pollutants, and para-amino hippurate
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8
Q

role of loop of henle

A
  • creates hyperosmotic medullary interstitium
  • separates reabsorption of water from reabsorption of solutes
  • important for concentrating urine
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9
Q

role of early distal tubule

A
  • dilute urine

- further reabsorption of Na+ causes additional dilution of forming urine

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10
Q

role of late distal tubule/collecting duct

A
  • hormones fine tune ion and water reabsorption
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11
Q

which hormones fine tune ion and water reabsorption

A
  • ADH
  • aldosterone
  • ANP
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12
Q

osmolality of tubular fluid in proximal tubule

A
  • isosmotic
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13
Q

osmolality of tubular fluid in loop of henle - enters how

A
  • enters isosmotic
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14
Q

osmolality of tubular fluid in loop of henle - bend of the loop of Henle is

A
  • hyperosmotic
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15
Q

osmolality of tubular fluid in loop of henle - exits

A
  • hypo-osmotic
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16
Q

early distal tubule reabsorbs

A
  • Na+ (but not water)
17
Q

osmolality of tubular fluid in early distal tubule

A
  • hypo osmotic
18
Q

osmolality of tubular fluid in late distal tubule and collecting duct

A
  • from hypo osmotic to hyper osmotic depending on hormonal regulation
19
Q

main purpose of juxtaglomerular apparatus

A
  • regulates fluid balance

- important for RAAS

20
Q

JGA formed by

A
  • specialized cells of afferent arteriole and distal tubule
21
Q

role of JGA cells

A
  • release renin into the blood
22
Q

renin released from JGA cells is stimulated by

A
  • decreased NaCl delivery to the macula densa
  • increased sympathetic efferent activity
  • decreased stretch of JG cell from decreased arterial BP
23
Q

effects of angiotensin II

A
  • constrict cardiovascular system
  • efferent arteriole constriction
  • activates Na+/H+ exchanger in the proximal tubule
  • increased ADH release