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MSN 6101 > Week 9 - Rheumatology And Connective Tissue Disorders > Flashcards

Week 9 - Rheumatology And Connective Tissue Disorders Flashcards

1
Q

Sx of ankylosising spondylitis

A

Constant Pain and Stiffness in the low back >3 months

Morning stiffness >30 minutes improved with exercise, not with rest. Alternating buttock pain. Awakening in 2nd half of the night d/t pain

Age <40 yo
Insidious onset

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2
Q

What gene is associated with ankylosising spondylitis?

A

HLA-B27

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3
Q

Dx of Ankylosing spondilytis

A

Physical exam including Schober’s test and Respiratory excursion (normal for both is at least 5 cm)

X-rays
HLA B27

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4
Q

What is a CT disorder characterized by recurring mouth and genital ulcers, uveitis and arthritis?

A

Behçet’s disease

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5
Q

Sx of Behçet’s disease

A 
Mouth ulcers
Skin lesions
Sores on genitals
Uveitis
Joint swelling
Inflammation
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6
Q

What tests make Dx of Behçet’s disease

A

None.

Signs and symptoms

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7
Q

An inflammatory CT disorder that affects skin, muscles, joints, esophagus, lungs, and heart

Purple or dark red rash may occur anywhere

Calcinosis

A

Dermatomyositis

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8
Q

Dermatomyositis Sx

A 
Dark red or purple skin rash
Dysphagia
Fatigue
Fever
Muscle pain, weakness
Unintentional weight loss
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9
Q

Dx of Dermatomyositis

A

None. Signs and symptoms.

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10
Q

Causes of fibromyalgia

A

Not known, but possibly:

Serotonin deficiency
Hypometabolism

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11
Q

Sx of fibromyalgia

A 
Fatigue 
Stiffness
Headache
Sleep disturbance
Anxiety
Coldness
Exercise intolerance
Dysmenorrhea
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12
Q

How to Dx fibromyalgia

A

Symptoms and Abnormal tenderness at 11 or more of 18 specific anatomical tender point sites

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13
Q

Increased ____ can cause gout

A

Uric acid

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14
Q

Elevated uric acid levels due to

A

Increased uric acid
Not eliminating uric acid
Or both: overproduction and underexcretion of uric acid

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15
Q

Primary gout is __% of all cases of gout

A

90%

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16
Q

Causes of secondary gout

A

Diuretics

Low-dose aspirin

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17
Q

Sx of gout

A

Pain and inflammation in one joint, fever and chills

50% big toe

18
Q

Causes of juvenile rheumatoid arthritis

A

Not known. Thought to be autoimmune

19
Q

Sx of juvenile rheumatoid arthritis

A

Inflammation in joint
Limping
Sudden high fever
Rash that comes and goes with fever

20
Q

Dx for juvenile rheumatoid arthritis

A 
Physical exam
Blood tests:
- rH factor
- ESR
- ANA
- CBC
- HLA B27
21
Q

Primary vs secondary osteoarthritis

A

Primary - old age

Secondary - obesity, trauma, surgery, congenital malformations in joint structure/function, etc.

22
Q

What is a persistent inflammatory muscle disease that causes weakness of muscles

A

Polymyositis

23
Q

Causes of polymyositis

A

Unknown, possibly autoimmune

24
Q

Sx of polymyositis

A 
Progressive mm weakness
Dysphagia
Difficulty speaking
Mild joint or mm tenderness
Fatigue
Shortness of breath
25
Q

Dx of polymyositis

A

MRI
Electromyography
Muscle biopsy
Blood tests - increased CK and aldolase suggest muscle damage

26
Q

Chronic inflammatory condition affecting the entire body, esp synovial membranes of joints

A

Rheumatoid arthritis

27
Q

What deformities are named in the hand with Rheumatoid arthritis?

A

Boutonnière deformity

Swan neck deformity

28
Q

Dx of Rheumatoid arthritis

A

RF factor in serum

Radiograph

29
Q

Buildup of scarlike tissue int he skin

A

Scleroderma

30
Q

Causes of scleroderma

A

Unknown. Autoimmune? Build up of collagen in the skin

31
Q

Sx of scleroderma

A

Skin hardening and tightening
Raynaud’s phenomenon
Acid reflux

32
Q

Dx scleroderma

A

Blood tests
Biopsies of skin
Breathing tests, CT lungs, echocardiogram of the heart

33
Q

An autoimmune disorder in which the glands that produce tears and saliva are destroyed

A

Sjogren syndrome

- dry mouth, dry eyes

34
Q

Primary vs secondary sjogren syndrome

A

1˚ is without other AI disorder

2˚ is with other AI disorder e.g. Rheumatoid arthritis, lupus, etc.

35
Q

Sx for sjogren syndrome

A

Dry eyes, mouth
Itching eyes
Dysphagia, loss of sense of taste, problems speaking
Fatigue

36
Q

Dx sjogren syndrome

A

Physical exam
ANA test
RH factor

37
Q

AI disease that leads to long-term inflammation that affects skin, joints, kidneys, brain, other organs

A

Systemic lupus erythematosus

38
Q

Characteristic sign of SLE

A

Butterfly rash on the face

39
Q

Sx of SLE

A 
Chest pain with deep breath
Fatigue
Hair loss
Mouth sores
*butterfly rash*
40
Q

Dx SLE

A

Antibody tests, ANA panel
CBC
Chest xray

41
Q

General term for inflammation of blood vessels

A

Vasculitis

42
Q

Dx vasculitis

A

Biopsy of involved tissue

MSN 6101 (10 decks)

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