Week 8 Drugs Flashcards
Alteplase Recombinant, TPA
Pharmacology and Actions
TPA promotes fibrinolysis by forming the active proteolytic enzyme plasmin. Plasmin in turn degrades fibrin, fibrinogen and the clot.
Alteplase Recombinant, TPA
Class
Fibrinolytic
Alteplase Recombinant, TPA
Indications
Fibrinolysis in acute myocardial infraction
Acute ischemic shock
Pulmonary embolism
Alteplase Recombinant, TPA
Contraindications
Internal bleeding Aortic emergencies Increased intracranial pressure Hemorrhagic shock within the past 6 months Uncontrolled hypertension
Alteplase Recombinant, TPA
Precautions and Side Effects
Internal bleeding
Superficial bleeding
Hemorrhagic stroke
Alteplase Recombinant, TPA
Dosage
Adult
MI/CVA: 15mg followed by 0.75mg/kg over 30min, max dose of 50mg, then provide 0.5mg/kg over 60min, max of 35mg.
Pulmonary embolism: 100mg infused over 2 hr
Pedi
Decadron
Class
Steroid
Decadron
Pharmacology and Actions
Prevents the accumulation of inflammatory cells at the sites of infection; inhibits phagocytosis, lysosomal enzyme releases, and synthesis of selected chemical mediators of inflammation.
Decadron
Indications
Anaphylaxis
Asthma
COPD
Acute spinal cord edema
Decadron
Contraindications
No absolute contraindications in the emergency setting
Decadron
Precautions and Side Effects
Arrhythmias
Hyperglycemia
CHF
Hypertension
Decadron
Dosage
Adult
4-24mg IV/IO/IM
Pedi
0.5-1.0mg/kg
Mannitol, Cystosol, Osmitrol
Class
Osmotic diuretic
Mannitol, Cystosol, Osmitrol
Pharmacology and Actions
Mannitol is an osmotic diuretic that draws water from the Intracellular space into the intravascular space through its hypertonic effects.
Mannitol, Cystosol, Osmitrol
Indications
To reduce acute cerebral edema and increased intracranial pressure.