Week 6 Drugs Flashcards
Amiodarone Cordarone
Pharmacology and Actions
AIS
- Prolongs the action potential and refractory period.
- Inhibits adrenergic stimulation.
- Slows the sinus rate, increases PR and QT intervals, and decreases peripheral vascular resistance.
Amiodarone Cordarone
Class
Antiarrhythmic
Amiodarone Cordarone
Indications
V-Fib/Pulseless V tach
Wide complex tachycardia with pulse
Amiodarone Cordarone
Contraindications
Hypersensitivity Cardiogenie shock Bradycardia AV blocks Liver disease
Amiodarone Cordarone
Precautions and Side Effects
Hypotension Bradycardia Cardiogenie shock Headache/Dizziness AV Block
Amiodarone Cordarone
Dosage
Adult
V-Fib/Pulseless V tach: 300mg IV/IO repeat at 150mg after 3-5 min
Wide complex tachycardia: 150mg IV/IO over 10 min
Post resuscitation maintenance: 1mg/min over 6 hr
Max dose: 2.2g IV/IO over 24 hr
Pedi
VF/Pulseless V tach: 5mg/kg IV/IO
Wide complex tachycardia: 5mg/kg IV/IO over 20-60 min
Max dose : 15mg/kg
Magnesium Sulfate
Class
Electrolyte
Magnesium Sulfate
Pharmacology and Actions
AD
- acts as a physiological calcium channel blocker, CNS depressant and anti-convulsant
- depresses the function of smooth, skeletal and cardiac muscles.
Magnesium Sulfate
Indications
HTEA
Hypomagnesaemia
Trosades de pointers
Eclamptic seizure
Adjunctive treatment in moderate to severe acute asthma
Magnesium Sulfate
Contraindications
Hypocalcaemia
Heart block
Myocardial damage
Anuria
Magnesium Sulfate
Precautions and Side Effects
ALOC
Hypotension
Heart block
Hypocalcemia
Magnesium Sulfate
Dosage
Adult
Torsades de pointes: 1-2g IVP over 1-2 min
Eclamptic seizure: 4-5g IVP concurrently with up to 5g IM in each buttock then 4-5g every 4 hr
Bronchodilation: 2g IVP
Pedi
Torsades de pointes: 25-50mg/kg/dose max dose of 2g
Bronchodilation: 25mg/kg/dose max 2g
Pralidoxime 2 PAM
Class
Cholinesterase reactivator
Pralidoxime 2 PAM
Pharmacology and Actions
RDR
- Reactivates the cholinesterase inhibited by phosphate esters displacing the enzyme from its receptor sites.
- restores normal functions of neuromuscular transmission.
Pralidoxime 2 PAM
Indications
Organophosphate poisoning