Week 8+9 Pancreas, Liver, Gallbladder Flashcards
deficient production of these enzymes by the pancreas.
pancreatice insufficiency
enzymes of pancrease
lipase
amylase
trypsin
chymotrypsin
Causes of pancreatic insufficiency
chronic pancreatitis, pancreatic carcinoma, pancreatic resection, and cystic fibrosis
chief problem with pancreatic insuffiency
fat maldigestion
risk factors for pancreatitis
alcoholism
obstructive biliary tract disease (particularly cholelithiasis)
peptic ulcers
abdominal trauma, hyperlipidemia
certain drugs
genetic factors (hereditary pancreatitis, cystic fibrosis)
develops because of obstruction to the outflow of pancreatic digestive enzymes caused by bile duct or pancreatic duct obstruction (e.g., gallstones).
pancreatitis
what happens with pancreatitis due to obstruction
-backup of pancreatic secretions causes activation and release of enzymes
-autodigestion (e.g., proteolysis, lipolysis) of pancreatic cells and tissues,resulting in inflammation
Clinical Manifestations of Acute Pancreatitis
-abdominal pain
-Fever and leukocytosis
-nausea vomiting
-ascites
_____and multiple organ failure account for most deaths with severe pancreatitis.
systemic inflammatory response syndrome (SIRS).
Cullen’s sign
In severe acute pancreatitis, some individuals develop flank or periumbilical ecchymosis, a sign of poor prognosis
lab marker for acute pancreatitis
- Elevated serum lipase level
- Serum amylase level is elevated
most common cause of chronic pancreatitis
chronic alcohol abuse
Chronic pancreatitis is a risk factor for
pancreatic cancer.
irreversible inflammatory, fibrotic liver disease
Cirrhosis
most common cause of cirrhosis
Alcohol abuse
viral hepatitis
does cirrhosis develop fast or slow
slowly over a period of time