Week 6 + 7- Digestive Flashcards
gram-negative spiral bacterium with a flagella and is a major cause of acute and chronic gastritis, peptic ulcer disease in the duodenum and stomach, gastric adenocarcinoma, and gastric mucosa–associated lymphoid tissue (MALT)
H pylori
how of you get H pylori
fecal transmission
childhood
an inflammatory disorder of the gastric mucosa
gastritis
Acute gastritis is usually caused by
-injury of the protective mucosal barrier by drugs, chemicals
-Helicobacter pylori infection
-NSAIDs
Nonsteroidal anti-inflammatory drugs inhibit the action of
cyclooxygenase-1 (COX-1)
loss of T-cell tolerance and development of autoantibodies to gastric H+-K+ ATPase.
chronic fundal gastritis
-Loss of parietal cells leads to low hydrochloric acid and intrinsic factor.
cause of Chronic antral gastritis
-alcohol
-h pylori
-tabacoo
-NSAIDs
-increased risk of duodenal ulcers.
atrophic gastritis.
-parietal cell antibodies present
-elevated plasma ghrelin level
-leads to pernicious anemia
a break, or ulceration, in the protective mucosal lining of the lower esophagus, stomach, or duodenum
peptic ulcer
Risk factors for peptic ulcer
-genetic
-H. pylori infection of the gastric mucosa
-NSAIDs.
Superficial ulcerations are called
erosions
True peptic ulcers
extend through the muscularis mucosae and damage blood vessels, causing hemorrhage or perforating the gastrointestinal wall.
most common peptic ulcer
duodenal ulcer
acid and pepsin concentrations in the duodenum to penetrate the mucosal barrier and lead to ulceration
duodenal ulcer
chronic intermittent pain in the epigastric area that begins 30 minutes to 2 hours after eating , when the stomach is empty.
duodenal ulcer
-pain relieved by eating
