Week 3- Adrenal Part 2 Flashcards
Primary hyperaldosteronism
Conn disease
caused by excessive secretion of aldosterone from an abnormality of the adrenal cortex, usually a single benign aldosterone-producing adrenal adenoma
hyperaldosteronism
Secondary hyperaldosteronism
-2ndary=renin issue, not adrenals
excessive aldosterone secretion from an extra-adrenal stimulus, most often angiotensin II through a renin-dependent mechanism. Diuretic use is perhaps the most common cause of secondary hyperaldosteronism
Hyperaldosteronism leads to
-increase sodium
-increase BP and volume
-decrease potassium
development of left ventricular dilation and hypertrophy, vascular disease, and renal disease is seen in what disease
Hyperaldosteronism
development of left ventricular dilation and hypertrophy, vascular disease, and renal disease is seen in what disease
Hyperaldosteronism
hyperaldosterom drug
spironolactone
Hypersecretion of adrenal androgens and estrogens may be caused by
- adrenal tumors (either adenomas or carcinomas)
- Cushing syndrome
- defects in steroid synthesis.
A form of hypocortisolism and primary adrenal insufficiency
Addisons disease
most common cause of Addison disease in the United States is
autoimmune destruction of the adrenal cortex
ddison disease is characterized by
- inadequate corticosteroid and mineralocorticoid synthesis
- elevated serum ACTH levels
antibodies associated with Addisons disease
21-Hydroxylase autoantibodies autoreactive T cells
skin changes with Addisons disease
hyperpigmentation and vitiligo,
greater concern with addisons
development of hypotension that can progress to complete vascular collapse and shock.
Addisons has low cortisol and high ______-
potassium
