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week 8 Flashcards

1
Q

Apixaban Brand

A

Eliquis

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2
Q

Apixaban class and IND

A

Factor Xa inhibitor

Prevention of stroke in non-valvular a-fib. DVT and PE treatment, VTE prophylaxis (Total hip or knee replacement)

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3
Q

Apixaban MOA

A

Directly binds to and inhibits factor Xa which is necessary for the generation of thrombin for thrombus formation

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4
Q

Apixaban AE

A

Bleeding, nausea, elevation in liver enzymes

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5
Q

Atenolol Brand

A

Tenormin

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6
Q

Atenolol Class and iND

A

Selective Beta-1-Blocker

Angina, HTN, Myocardial Infarction
Off Label: A-fib, SVT

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7
Q

Atenolol MOA

A

Inhibits beta-1 receptors in the heart resulting in a reduction of the pulse and cardiac output that can lower the blood pressure

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8
Q

Atenolol AE

A

Bradycardia, bronchospasm, fatigue, hypotension, depression, sexual dysfunction

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9
Q

Atorvastatin brand

A

Lipitor

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10
Q

Atorvastatin Class and IND

A

Statin ( HMG-CoA Reducatase Inhibitor)

Hyperlipidemia, Familial hyperlipidemia, Primary and seconday of atherosclerotic CVD

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11
Q

Atorvastatin AE

A

Hyperglycemia, liver enzymes elevation, myalgia, myositis (elevation in CK), rhabdomyolysis

CI in pregnancy

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12
Q

Benazepril Brand

A

Lotensin

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13
Q

Benazepril class and IND

A

ACE-I

HTN >6 years old

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14
Q

Benazepril MOA

A

In the enzymes, angiotensin converting enzyme (ACE), which is needed to convert angiotensin 1 to angiotensin 2

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15
Q

Benazepril AE

A

Angioedema, cough (dry cough), hyperkalemia, worsening renal function, hypotension

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16
Q

Bisoprolol brand

A

Zebeta

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17
Q

Bisoprolol class and IND

A

Selective Beta 1 blocker

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18
Q

Bisoprolol MOA

A

The inhibition of the beta-1 receptors in the heart are known to facilitate a reduction in chronotropy and inotropy resulting in a reduction of the pulse and cardiac output that can lower the blood pressure.

Some vasoconstriction due to some degree of beta2 antagonism.

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19
Q

Bisoprolol AE

A

Bradycardia, bronchospasm, fatigue, hypotension, depression, sexual dysfunction

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20
Q

Candesartan Brand

A

Atacand

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21
Q

Candesartan class and IND

A

ARB

Heart Failure, HTN, Left ventricular dysfunction post MI
Off-Label: Angina, a fib, cardiac dysrhythmias

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22
Q

Candesartan MOA

A

Selectively antagonizes the angiotensin 2 receptor which leads to a reduction in afterload and vascular/cardiac remodeling

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23
Q

Candesartan AE

A

Angioedema, cough, hyperkalemia, worsening renal function, hypotension

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24
Q

Carvedilol Brand

A

Coreg

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25
Carvedilol class and IND
Mixed alpha/beta blocker
26
Carvedilol MOA
Selectively inhibits alpha 1 mediated vascoconstrictive effects on arteries to reduce blood pressure and also function as a non-selective beta-blocker which can reduce the pulse, stroke volume, cardiac output, and vascular remodeling.
27
Carvedilol AE
Braycardia, bronchospasm, depression, dizziness, fatigue, hypotenstion, sexual dysfunction
28
Clonidine brand
Catapres
29
Clonidine class and IND
Centrally acting alpha 2 agonist ADHD, HTN Off-Label: Acute HTN, Hot swets, Nicotine and opiod withdraw, spasticity, tourette syndrome
30
Clonidine MOA
Functions as an agonist at the pre-synaptinc alpha 2 receptor in the CNS and results in a decreased release of NE and overall sympathetic outflow to target organs
31
Clonidine AE
Bradycardia, constipation, fatigue, HTN and tachycardia, hypotension, sedation, xerostomia
32
Dabigatran brand
Pradaxa
33
Dabigatran class and IND
Anticoagulant DVT & PE, DVT prevention after hip replacement, stroke prevention
34
Dabigatran MOA
Reversible and direct inhibition of the thrombin which is needed in the formation of a clot and does not need the presences of antithrombin in order to work
35
Dabigatran AE
Bleeding, dyspepsia, gastritis
36
Febuxostat brand
Uloric
37
Febuxostat class and IND
Xanthine Oxidase inhibitor Hyperuricemia
38
Febuxostat MOA
Inhibits the enzyme, xanthine oxidase, which is responsible for converting xanthine to uric acid, which is more water soluble.
39
Febuxostat AE
Nausea, increat Liver enzymes, rash, arthralgia
40
Felodipine brand
Plendil
41
Felodipine class and IND
CCB (Dihydro)
42
Felodipine MOA
Inhibits the calcium channels within the smooth muscle cells of arteries thereby reducing the cytosolic calcium concentrations that allow for contraction
43
Felodipine AE
Constipation, reflux, peripheral and lower extremity edema, reduction in BP, reflex tachycardia
44
Irbesartan brand
Avapro
45
Irbesartan class and IND
ARB Diabetic nephropathy, HTN
46
Irbesartan MOA
Selectively antagonizes the angiotensin 2 receptor which leads to a reduction i n afterload and vascular/cardiac remodeling
47
Irbesartan AE
Angioedema, hyperkalemia, worsening renal function, hypotension
48
Isosorbide Mononitrate brand
Imdur
49
Isosorbide Mononitrate class and IND
Long acting nitrate, vasodilator Angina pectoris
50
Isosorbide Mononitrate MOA
After being convertd to nitric oxide in the vasculature, it activated the intracellular enzyme, guanylate cyclase which then incerases cGMP mediated pathways within smooth muscle cells lining the blood vessels to reduce cystolic calcium levels that reduce actin/myosin interaction and eventually lead to vasodilation.
51
Isosorbide Mononitrate AE
Dizziness, HA flushin, hypotension, orthostasis
52
Nebivolol brand
Bystolic
53
Nebivolol class and IND
Selective Beta 1 blocker HTN
54
Nebivolol MOA
Inhibition o f beta 1 receptors in t he heart are known to facilitate a reduction in chronotropy and inotropy resulting in a reduction of the p ulse and cardiac out that can l ower the blood pressure
55
Nevivolol AE
Bradycardia, bronchospasm, fatigue, hypotension, depression, sexual dysfunction
56
Valsartan Brand
Diovan
57
Valsartan Class and IND
ARB Heart failure, HTN, MI
58
Valsartan MOA
Antagonizes angiotensin 2 receptor which leads to a reduction in afterload and vascular/cardiac remodeling
59
Valsartan AE
Angioedema, cough, hyperkalemia, worsening renal function, hypotension
60
Verapamil brand
Calan, Verelan
61
Verapamil class and IND
NHD CCB HTN, Angina, Atrial tachydysrhythmias
62
Verapamil MOA
Inhibits calcium from entering into the myocardial and vascular smooth muscle via the voltage sensitive calcium channels, thereby reducing the interaction of actin and myosin.
63
Verapamil AE
Bradycardia, constipation, dizziness, edema, fatigue, gingival hyperplasia, worsening heart failure, heart block

Patient Care (11 decks)

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