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Patient Care > PPCP 2 Quiz 3 > Flashcards

PPCP 2 Quiz 3 Flashcards

1
Q

Enalopril Brand & Indication

A

Vasotec

HTN, Heart Failure
Off-Label: Diabetic Nephropathy

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2
Q

Enalapril Class

A

ACE-I

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3
Q

Enalapril MOA

A

In the enzymes, Angiotensin Converting Ezyme (ACE), which is needed to convert angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction of the arteries that can raise blood pressure (or afterload).

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4
Q

Enalopril AE

A

Hyperkalemia
Angioedema
DRY COUGH
Hypotension

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5
Q

Enalapril is CI in

A

Pregnancy

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6
Q

Ramipril Brand & indication

A

Altace

HTN, Heart failure post MI, Diabetic Nephropathy

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7
Q

Ramipril MOA

A

In the enzymes, Angiotensin Converting Ezyme (ACE), which is needed to convert angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction of the arteries that can raise blood pressure (or afterload

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8
Q

Ramipril AE

A

Hyperkalemia, Angiodema, dry cough, worsening renal function, hypotension.

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9
Q

Ramipril CI

A

Pregnancy 2nd/3rd trimester

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10
Q

Valsartan Brand & Indication

A

Diovan
ARB
Heart failure, HTN, MI

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11
Q

Valsartan MOA

A

Selectively antagonizes the Angiotensin II (Type 1) Receptor which leads to reduction n afterload and vascular/cardiac remodeling.

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12
Q

Valsartan AE

A

Angiodema, dry cough, hyperkalmeia, worsening renal function, hypotension..

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13
Q

Valsartan CI

A

Pregnancy

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14
Q

Furosemide Brand & Indication

A

Lasix

Edema (secondary to heart failure & renal failure); Acute pulmonary edema; Hypertension

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15
Q

Furosemide

A

Inhibits Na/K/2Cl co-transporter in thick ascending Loop of Henle to prevent reabsorption of luminal Na and water thereby increasing fluid loss in urine.

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16
Q

Furosemide AE

A

Dizziness, increased uric acid levels (exacerbating gout), increased urination, ototoxicity at high doses, tinnitus, reductions in Na+, K+, Ca2+, Mg2+

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17
Q

Important info about Furosemide…

A

-Name Lasix come about as it was known to “Last about six hours”.

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18
Q

Spironolactone brand & indication

A

Aldactone

Heart failure (NYHA Class III-IV), Edema from heart failure, Nephrotic syndrome, hypertension, hpokalemia.

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19
Q

Spironolactone AE

A

Breast tenderness, change in menustration, indigestion, gynecomastia, hyperkalmeia, hyponatremia, lethargy.

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20
Q

Spironolactone MOA

A

Antagonizes the effects of Aldosterone in the distal and collecting tubes of the nephron to prevent reabsorption of sodium and water from urine filtrate thereby causing a mild diuresis.

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21
Q

Spironolactone Class

A

Pot sparing diuretic; Aldosterone Antagonist

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22
Q

Dutasteride brand & indication

A

Avodart
BPH (Benign prostatic hyperplasia)-enlargement of the prostate gland common in older men.
-Off label-Alopecia in males

23
Q

Dutasteride Class

A

5-Alpha Reductase Inhibitor

24
Q

Dutasteride MOA

A

Prevents the conversion of testosterone to more potent form, Dihydrotestosterone by inhibiting 5-alpha reductase. End result is reducing the size of prostate to decrease residual urine volume and improve urinary flow.

25
Q

Dutasteride AE

A

Dizziness, gynecomastia, impotence, reduced libido

26
Q

Dutasteride CI

A

Pregnancy

27
Q

Tamsulosin brand & indication

A 
Flomax
BPH (Benign prostatic hyperplasia)-enlargement of the prostate gland common in older men.
28
Q

Tamsulosin MOA

A

Selectively blocks Alpha-1a receptors in the bladder to increase urine flow by relaxing smooth muscle tone in the bladder neck & prostate thus leading to a reduction in residual urine volume and increased urine flow.

29
Q

Tamsulosin AE

A

Dizziness, abnormal ejaculation, hypotension, orthostasis, somnolence.

30
Q

Solfenacin brand & indication

A

Vesicare

Overactive Bladder-helps with urine incontinence, bladder spasms, and urinary urgency

31
Q

Solifenacin MOA

A

Competitively binds to and antagonizes Muscarinic Receptors in the smooth muscles of the urinary bladder.

32
Q

Solifenacin AE

A

Constipation, dry mouth, blurry vision, urinary retention, dizziness.

33
Q

Darifenacin brand & indication

A

Enablex

Overactive Bladder - helps with urine incontinence, bladder spasms, and urinary urgency.

34
Q

Darifenacin MOA

A

Competitively binds to and antagonizes Muscarinic Receptors in the smooth muscles of the urinary bladder.

35
Q

Darifenacin AE

A

Constipation, dry mouth, blurry vision, urinary retention, dizziness.

36
Q

Ibandronate brand & indication

A

Boniva

Osteoporosis (given to postmenopausal women for treatment and prophylaxis.)

37
Q

Ibandronate MOA

A

Inhibits the ability of osteoclasts from being able to breakdown (i.e. resorption) bone by forming a bond with hydroxyapatite.

38
Q

Ibandronate AE

A

bone pain, gastritis, myalgia, osteonecrosis of jaw.

39
Q

Ibandronate CI

A

CrCl<30 ml/min

40
Q

Methotrexate brand & indication

A

Trexall
Acute Lymphoblastic Leukemia, Non-Hodgkin Lymphoma, Burkitt Lymphoma, Osteosarcoma, Psoriasis, RA, JRA.

DMARD

41
Q

Methotrexate MOA

A

Reversibly inhibits the enzyme, Dihydrofolate Reductase, responsible for converting folate to tetrahydrofolte so that DNA can be made in replicating cells.

42
Q

MEthotrexate AE

A

Alopecia (w/Larger doses), GI: nausea, vomiting, diarrhea, increased liver enzymes, myelosuppression, malignancies, stomatitis.

43
Q

Methotrexate CI

A

Pregnancy

44
Q

Pramipexole brand & indication, class

A

Mirapex
Parkinson’s Disease; Restless Leg Syndrome

Anti-Parkinson Agent;Dopamine Agonist

45
Q

Pramipexole MOA

A

Non-ergot derived dopamine agonist to D2 & D3 receptors in the CNS thought to help with akinesia, muscle rigidity and gait disturbances of Parkinson’s Disease.

46
Q

Pramipexole Off Label IND…

A

Bipolar depression; Fibromyalgia.

47
Q

Pramipexole AE

A

Dyskinesis (difficulty in performing voluntary movements), EPS (extrapyramidal symptoms), dream disorder, confusion, compulsive and impulsive behavior (gambling, hypersexuality, compulsive eating or buying), hallucinations, hypotension, melanoma, orthostasis.

48
Q

Ranolazine brand and indication, Class

A

Ranexa

Chronic Angina

Antianginal Agent

49
Q

Ranolazine MOA

A

Reduces ventricular myocardial muscle tension and oxygen consumption by inhibiting the inward Na+ channels during cardiac repolarization which then reduces the calcium influx that is needed intracellularly for actin and myosin to interact.

50
Q

Ranolazine AE

A

Bradycardia, hypotension, dizziness, blurred vision, QT Prolongation

51
Q

Colchicine brand and indication, Class

A

Colcrys
Gout (acute & prophylaxis); Familial Mediterranean Fever

Antigout

52
Q

Colchicine MOA

A

Mechanism is multifactorial inhibits beta-tubulin polymerase into microtubules that prevents the activation and migration of neutrophils.

53
Q

Colchicine AE

A

Diarrhea, nausea, vomiting

54
Q

Colchicine CI

A

Pregnancy

Patient Care (11 decks)

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