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Patient Care > PPCP 2 Quiz 3 > Flashcards

PPCP 2 Quiz 3 Flashcards

1
Q

Enalopril Brand & Indication

A

Vasotec

HTN, Heart Failure
Off-Label: Diabetic Nephropathy

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2
Q

Enalapril Class

A

ACE-I

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3
Q

Enalapril MOA

A

In the enzymes, Angiotensin Converting Ezyme (ACE), which is needed to convert angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction of the arteries that can raise blood pressure (or afterload).

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4
Q

Enalopril AE

A

Hyperkalemia
Angioedema
DRY COUGH
Hypotension

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5
Q

Enalapril is CI in

A

Pregnancy

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6
Q

Ramipril Brand & indication

A

Altace

HTN, Heart failure post MI, Diabetic Nephropathy

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7
Q

Ramipril MOA

A

In the enzymes, Angiotensin Converting Ezyme (ACE), which is needed to convert angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction of the arteries that can raise blood pressure (or afterload

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8
Q

Ramipril AE

A

Hyperkalemia, Angiodema, dry cough, worsening renal function, hypotension.

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9
Q

Ramipril CI

A

Pregnancy 2nd/3rd trimester

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10
Q

Valsartan Brand & Indication

A

Diovan
ARB
Heart failure, HTN, MI

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11
Q

Valsartan MOA

A

Selectively antagonizes the Angiotensin II (Type 1) Receptor which leads to reduction n afterload and vascular/cardiac remodeling.

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12
Q

Valsartan AE

A

Angiodema, dry cough, hyperkalmeia, worsening renal function, hypotension..

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13
Q

Valsartan CI

A

Pregnancy

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14
Q

Furosemide Brand & Indication

A

Lasix

Edema (secondary to heart failure & renal failure); Acute pulmonary edema; Hypertension

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15
Q

Furosemide

A

Inhibits Na/K/2Cl co-transporter in thick ascending Loop of Henle to prevent reabsorption of luminal Na and water thereby increasing fluid loss in urine.

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16
Q

Furosemide AE

A

Dizziness, increased uric acid levels (exacerbating gout), increased urination, ototoxicity at high doses, tinnitus, reductions in Na+, K+, Ca2+, Mg2+

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17
Q

Important info about Furosemide…

A

-Name Lasix come about as it was known to “Last about six hours”.

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18
Q

Spironolactone brand & indication

A

Aldactone

Heart failure (NYHA Class III-IV), Edema from heart failure, Nephrotic syndrome, hypertension, hpokalemia.

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19
Q

Spironolactone AE

A

Breast tenderness, change in menustration, indigestion, gynecomastia, hyperkalmeia, hyponatremia, lethargy.

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20
Q

Spironolactone MOA

A

Antagonizes the effects of Aldosterone in the distal and collecting tubes of the nephron to prevent reabsorption of sodium and water from urine filtrate thereby causing a mild diuresis.

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21
Q

Spironolactone Class

A

Pot sparing diuretic; Aldosterone Antagonist

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22
Q

Dutasteride brand & indication

A

Avodart
BPH (Benign prostatic hyperplasia)-enlargement of the prostate gland common in older men.
-Off label-Alopecia in males

23
Q

Dutasteride Class

A

5-Alpha Reductase Inhibitor

24
Q

Dutasteride MOA

A

Prevents the conversion of testosterone to more potent form, Dihydrotestosterone by inhibiting 5-alpha reductase. End result is reducing the size of prostate to decrease residual urine volume and improve urinary flow.

25
Dutasteride AE
Dizziness, gynecomastia, impotence, reduced libido
26
Dutasteride CI
Pregnancy
27
Tamsulosin brand & indication
``` Flomax BPH (Benign prostatic hyperplasia)-enlargement of the prostate gland common in older men. ```
28
Tamsulosin MOA
Selectively blocks Alpha-1a receptors in the bladder to increase urine flow by relaxing smooth muscle tone in the bladder neck & prostate thus leading to a reduction in residual urine volume and increased urine flow.
29
Tamsulosin AE
Dizziness, abnormal ejaculation, hypotension, orthostasis, somnolence.
30
Solfenacin brand & indication
Vesicare | Overactive Bladder-helps with urine incontinence, bladder spasms, and urinary urgency
31
Solifenacin MOA
Competitively binds to and antagonizes Muscarinic Receptors in the smooth muscles of the urinary bladder.
32
Solifenacin AE
Constipation, dry mouth, blurry vision, urinary retention, dizziness.
33
Darifenacin brand & indication
Enablex | Overactive Bladder - helps with urine incontinence, bladder spasms, and urinary urgency.
34
Darifenacin MOA
Competitively binds to and antagonizes Muscarinic Receptors in the smooth muscles of the urinary bladder.
35
Darifenacin AE
Constipation, dry mouth, blurry vision, urinary retention, dizziness.
36
Ibandronate brand & indication
Boniva | Osteoporosis (given to postmenopausal women for treatment and prophylaxis.)
37
Ibandronate MOA
Inhibits the ability of osteoclasts from being able to breakdown (i.e. resorption) bone by forming a bond with hydroxyapatite.
38
Ibandronate AE
bone pain, gastritis, myalgia, osteonecrosis of jaw.
39
Ibandronate CI
CrCl<30 ml/min
40
Methotrexate brand & indication
Trexall Acute Lymphoblastic Leukemia, Non-Hodgkin Lymphoma, Burkitt Lymphoma, Osteosarcoma, Psoriasis, RA, JRA. DMARD
41
Methotrexate MOA
Reversibly inhibits the enzyme, Dihydrofolate Reductase, responsible for converting folate to tetrahydrofolte so that DNA can be made in replicating cells.
42
MEthotrexate AE
Alopecia (w/Larger doses), GI: nausea, vomiting, diarrhea, increased liver enzymes, myelosuppression, malignancies, stomatitis.
43
Methotrexate CI
Pregnancy
44
Pramipexole brand & indication, class
Mirapex Parkinson's Disease; Restless Leg Syndrome Anti-Parkinson Agent;Dopamine Agonist
45
Pramipexole MOA
Non-ergot derived dopamine agonist to D2 & D3 receptors in the CNS thought to help with akinesia, muscle rigidity and gait disturbances of Parkinson's Disease.
46
Pramipexole Off Label IND...
Bipolar depression; Fibromyalgia.
47
Pramipexole AE
Dyskinesis (difficulty in performing voluntary movements), EPS (extrapyramidal symptoms), dream disorder, confusion, compulsive and impulsive behavior (gambling, hypersexuality, compulsive eating or buying), hallucinations, hypotension, melanoma, orthostasis.
48
Ranolazine brand and indication, Class
Ranexa Chronic Angina Antianginal Agent
49
Ranolazine MOA
Reduces ventricular myocardial muscle tension and oxygen consumption by inhibiting the inward Na+ channels during cardiac repolarization which then reduces the calcium influx that is needed intracellularly for actin and myosin to interact.
50
Ranolazine AE
Bradycardia, hypotension, dizziness, blurred vision, QT Prolongation
51
Colchicine brand and indication, Class
Colcrys Gout (acute & prophylaxis); Familial Mediterranean Fever Antigout
52
Colchicine MOA
Mechanism is multifactorial inhibits beta-tubulin polymerase into microtubules that prevents the activation and migration of neutrophils.
53
Colchicine AE
Diarrhea, nausea, vomiting
54
Colchicine CI
Pregnancy

Patient Care (11 decks)

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