Week 6

Question 1

97% of Staphylococcus aureus isolated in human produce the enzyme

Answer 1

Coagulase

Question 2

enzyme that reacts with the blood factor in the plasma to initiate clot formation

Answer 2

Coagulase

Question 3

enhance the deposition of the fibrin around the organism to protect them from phagocytosis

Question 4

counteracts the action of fatty substances secreted by the body

Answer 4

Lipase

Question 5

help in the colonization of organism – oily skin surfaces

Answer 5

Lipase

Question 6

found in the intracellular ground substance of connective tissue

Answer 6

Hyaluronidase

Question 7

promote invasion of organism by digesting the intracellular ground substance “glue” (hyaluronic acid) that binds connective tissue in host tissue

Answer 7

Hyaluronidase

Question 8

proteolytic enzyme with fibrinolytic activity

Answer 8

Staphylokinase

Question 9

causes dissolution of clot – spread infection further

Answer 9

Staphylokinase

Question 10

enzymatically and antigenically distinct from Streptokinase of Streptococci

Answer 10

Staphylokinase

Question 11

Production by most strain of Staphylococcus

Answer 11

Staphylokinase

Question 12

degrade nucleic acid DNA

Answer 12

Nuclease (DNAse)

Question 13

most specific test for Staphylococcus aureus

Answer 13

Nuclease (DNAse)

Question 14

found in cell surfaces of 90% - 96% of Staphylococcus aureus

Answer 14

Nuclease (DNAse)

Question 15

lyse RBC by destroying their membrane

Answer 15

Hemolysins/Cytolytic Toxins

Question 16

producing tissue damage;

Answer 16

Hemolysins/Cytolytic Toxins

Question 17

abscess formation

Answer 17

Hemolysins/Cytolytic Toxins

Question 18

Chromosomal mediated

Answer 18

Hemolysins/Cytolytic Toxins

Question 19

A heterogenous protein that acts on a broad spectrum of eukaryotic cell membranes.

Answer 19

A Hemolysin

Question 20

Degrades sphingomyelin, and is therefore toxic for many kinds of cells including human red blood cells

Answer 20

B toxin

Question 21

most powerful toxin that lyses RBC of various animals (platelets and macrophages= tissue damage)

Answer 21

A-hemolysis

Question 22

produce hemolysis in blood agar medium

Answer 22

A hemolysis

Question 23

Predominant hemolysin produced by S. aureus

Answer 23

A-hemolysin

Question 24

Heat labile

Answer 24

B toxin

Question 25

heterogenous and dissociates into subunits in non – ionic detergents.

Answer 25

8 Toxin

Question 26

Disrupts biologic membranes and may have a role in Staphylococcus aureus diarrheal diseases.

Answer 26

8 toxin

Question 27

Active against macrophages, lymphocytes, and neutrophil.

Answer 27

8 toxin

Question 28

A leukocidin that lyses white blood cells.

Answer 28

Y toxin

Question 29

Composed of two proteins designated S and F which may interact with the two proteins of Panton – Valentine Leukocidin.

Answer 29

Y Toxin

Question 30

composed of two (2) protein components that can kills white blood cells of humans and incapacitate the phagocytic line of the defense of the host. (cause pore formation in the cellular membrane necrosis and severe inflammation)

Answer 30

Panton – Valentine Leukocidin

Question 31

An important virulence factor in CA – MRSA infections.

Answer 31

Panton – Valentine Leukocidin

Question 32

Encoded on a mobile phage

Answer 32

Panton – Valentine Leukocidin

Question 33

stable and resistant to the action of gut enzymes

Answer 33

Heat

Question 34

Produce when Staphylococcus aureus grows in carbohydrate and protein foods.

Answer 34

Enterotoxins

Question 35

Most often EXCRETED from the cell; but some accumulate inside the cell are either injected directly or are released by cell lysis.

Answer 35

Enterotoxins

Question 36

Types of enterotoxins: most frequently associated with Staphylococcus food poisoning

Answer 36

A & D

Question 37

Types of enterotoxins: associated with hospital acquired infection (nosocomial); ingestion of 25μg results in vomiting and diarrhea (pseudomembranous enterocolitis- milk product)

Answer 37

B

Question 38

Types of enterotoxins: Recently recognize toxin, associated with toxic shock syndrome

Answer 38

F

Question 39

2 types of Exfoliative Toxins

Answer 39

Exfoliative Toxin A & Exfoliative Toxin B