Streptococci 2 Flashcards
act as superantigens, which stimulate T cells by binding to the class II major histocompatibility complex.
Streptococal Pyrogenic Exotoxin: A, B, C
Erythrogenic Toxin
associated with streptococcal toxic shock syndrome and scarlet feve
Streptococal Pyrogenic Exotoxin: A, B, C
Erythrogenic Toxin
the sore throat occurs as a subacute nasopharyngitis with a thin serous discharge
PHARYNGITIS In infants and small children
little fever but with a tendency of the infection to extend to the middle ear and the mastoid
PHARYNGITIS In infants and small children
cervical lymph nodes are usually enlarged;
The illness may persist for weeks.
PHARYNGITIS In infants and small children
more acute and is characterized by intense nasopharyngitis, tonsillitis, and intense redness and edema of the mucous membranes, with purulent exudate, enlarged, tender cervical lymph nodes, and (usually) a high fever.
PHARYNGITIS In older children and adults
DIRECT INVASION - PYOGENIC: SKIN INFECTION of Streptococcus pyogenes
Erysipelas
Impetigo (Streptococcal pyoderma)
Cellulitis
Necrotizing fasciitis (streptococcal gangrene)
Characterized by massive brawny edema and a rapidly advancing margin of infection
Erysipelas
It consists of superficial vesicles that break down and eroded areas whose denuded surface is covered with pus and later is encrusted
Impetigo (Streptococcal pyoderma)
Spreads by continuity and is highly communicable, especially in hot, humid climates.
Impetigo (Streptococcal pyoderma)
More widespread infection occurs in eczematous or wounded skin or in burns
Impetigo (Streptococcal pyoderma)
Follows infection associated with mild trauma, burns, wounds, or surgical incisions; pain, tenderness, swelling, and erythema occur.
Cellulitis
the lesion is not raised, and the line between the involved and uninvolved tissue is indistinct
Cellulitis
infection of the subcutaneous tissues and fascia
Necrotizing fasciitis (streptococcal gangrene)
What group of streptococci that cause necrotizing fasciitis have sometimes been termed “flesh-eating bacteria
Group A streptococci
Streptococcus pyogenes:
Poststreptococcal Diseases – IMMUNOLOGIC DISEASE
Acute glomerulonephritis
Rheumatic fever
initiated by antigen–antibody complexes on the glomerular basement membrane
Acute glomerulonephritis
develops 1–4 weeks after S pyogenes skin infection (pyoderma, impetigo)
Acute glomerulonephritis
after random streptococcal skin infections, the incidence of nephritis is
less than 0.5%
characterized by blood and protein in the urine, edema, high blood pressure, and urea nitrogen retention; serum complement levels are also low.
Acute glomerulonephritis
most serious sequela of S pyogenes because it results in damage to heart muscle and valves
Rheumatic fever
Patients with more severe streptococcal sore throats have a greater chance of developing
Rheumatic fever
the onset of Rheumatic fever is often preceded by S pyogenes infection
1–4 weeks earlier
Typical S/S include fever, malaise, a migratory nonsuppurative polyarthritis, and evidence of inflammation of all parts of the heart
Rheumatic fever
Streptococcus pyogenes : TREATMENT
- Doses of Penicillin and Erythromycin for 8 days
- Allergic Patient: Clindamycin, Erythromycin, Cephalexin
- Benzathine PCN given for 10 days IM
Habitat: Female genital tract and lower gastrointestinal tract
Occasional colonizer of upper respiratory tract
Streptococcus agalactiae