Week 4 Flashcards
Which agent of infection is a more complex single-celled organism containing nuclei and organelles?
Protozoa
What is an infection that is always present and never fully disappears?
Endemic Infection
Which immunity type are T Lymphocytes responsible for?
Primarily involved in viral & fungal immunity
What is the inflammatory response to Viral infections?
(What is released)
- Lymphocytes
- Monocytes
- Few Neutrophils
What is a vector-borne infection?
This is an infection type that has a vector or “middle man” usually animal-based that transmits the illness to humans.
- Lyme disease (Ticks)
- Malaria (Mosquitoes)
- The Plague (Rats)
What factors affect the immune system?
- Stress
- Malnutrition
- Drugs
- Radiation
- Toxins
- Concurrent illness and disease
- Surgery and anesthesia
- Splenectomy
- Sleep deprivation
- Large amounts of aerobic exercise or demanding events
What is the purpose of the antigen-antibody complexes?
To circulate in the blood and provoke an inflammatory response in tissues where they lodge.
What type of infection is Bronchitis?
Viral infection
What is the function of IgE?
Primarily in tissue, and reacts to pollen & other non-bacterial antigens (parasites & allergies)
What is the inflammatory response to Mycobacteria & Fungal infections?
(What is released)
- Lymphocytes
- Monocytes
- Granulomas
What is the primary purpose of IgG?
To develop a “memory” of previously exposed response to a pathogen
What are the components of the adaptive immune system?
- It is programmable
- Contains antigens
- Contains antibodies
- Contains Macrophages & Dendritic cells
- Contains B Lymphocytes
- Contains T Lymphocytes
How do bacteria typically cause microbiological injury?
Through the release of either endo/exotoxins
What are the agents of Infection?
- Prions
- Viruses
- Bacteria
- Protozoa
- Fungi
- Ectoparasites
- Multicellular parasites
What is contact transmission?
Where infection or spread is the result of direct contact
What is the term used to describe an increased infection rate?
Epidemic
What is the primary role of immunoglobulins?
- Primarily antibacterial in nature
- Recognize and Binding to particular antigens
How is an antigen impacted when a plasma cell binds to it?
- It blocks normal function of the anigen
- Ruptures the cell membrane causing death
- Incites inflammatory response which results in neutralization or digestion of the microbe
- Makes the cell more susceptible to phagocytosis
What are some signs and symptoms of an infection?
-
Local
- Swelling
- Redness
- Warmth
- Pain
-
Systemic
- Fever
- Malaise (Dizzy)
- Myalgia (pain)
- Loss of appetite
- Fatigue
-
Organ specific
- Jaundice
- Cough
- Headache
- Emesis (Vomiting)
-
Laboratory findings
- Elevated WBC
- Granulocytes
- CRP
- Microbial culture
At what phase of infection would you see a spike in pathological forces?
3rd phase, illness with typical symptoms
What are the roles of T Lymphocytes?
- To kill certain types of non-self cells via the release of Cytotoxic T cells (Killer T Cells)
- Modulate the response of B lymphocyte immune reaction
What are some examples of Anaerobic Baccili?
- Clostridium tetani (tetanus)
- C. Botulinum (From canned foods, you would see a bulge in the can)
- “The Can I BOT at the store is dented”
How do T Lymphocytes function in adaptive immunity?
Unlike B lymphocytes, T Lymphocytes go to directly attack the pathogen.
What is rheumatoid arthritis?
- A chronic inflammatory polyarthritis
- Invasive synovitis triggered by autoimmunity which leads to joint destruction and ankylosis (fused bones or other hard tissue)
- Inflammation of synovial tissue and fluid leading to change that destroy cartilage and bone
- Other organs may be affected
What is the term used to describe the population where infection lives?
Reservoir
What is Kaposi’s Sarcoma?
a type of cancer that forms in the lining of blood and lymph vessels.
What immune cell type does AIDS primarily infect?
CD4+ cells (Helper T cells)
What is a visual sign of Lupus?
A butterfly-shaped rash on the face after exposure to UV
What is a type 4 hypersensitivity disease?
Cellular (Delayed) Hypersensitivity
- The result of T, not B Lymphocytes
- No antibodies, take longer to develop (days)
- Macrophages accumulate around the antigen forming a growth of T lymphocytes with a necrotic center
- Creates a hypersensitivity to cytotoxic cells
If I fall into poison ivy and have a delayed reaction to it, what cell and hypersensitivity classification is this an example of?
This is a T-cell immune response and the classification type is 4
Autoimmune diseases are usually what type of hypersensitivity disease?
Type 3 (Immune-Complex) Hypersensitivity
What is Atopy?
general predisposition to allergies