Week 1 Flashcards
Why does inflammation feel hot?
this is due to increased cellular activity and metabolism
What is the vascular response of/to injury?
- Initial vasoconstriction
- Vasodilation
- Margination and pavement of WBC
- Diapedesis of WBC (passage of blood cells through intact walls of capillaries)
- Emigration of WBC
- Increase in permeability
- Edema fromation
What is the inflammatory response to injury?
Through a joint cellular and vascular response injured cells:
- Increase blood flow
- Attract WBC
- Cause vessels to become leaky
- allow plasma and cells to move towards injured cell due to increased permeability
What is scarring?
Scarring is the replacement of normal tissue with connective tissue (collagen)
What is the sensitivity of a test?
ability to be positive in the PRESENCE of disease
What happens to positive predictive value if specificity is low?
It will also be low
What are the three main types of inflammatory exudate?
- Serous (fluid in a blister)
- Fibrinous (scabs)
- Suppurative (pimples)
Which cells are the main responders to chronic inflammation?
Lymphocytes and monocytes (macrophages)
What is Ischemia?
Lack of oxygen due to lack of blood flow.
What is the main cell activated during acute inflammation? Why?
Neutrophils, because they clean up bacteria and attract WBC
Why is inflammation red (rubor)?
Increased vasodialation
“If this organ is damaged it may cause an impaired inflammatory response. “
The Liver!
What is the purpose of inflammation?
- Limits extent of injury
- Eliminates or neutralizes damaging agent
- Initiates the healing process
What happens to negative predictive value if sensitivity is low?
It will also be low
What is the difference between transudate edema and exudated edema?
Transudate edema is the loss of fluid through a damaged cell where as exudated edema is the loss of fluid and proteins through a damaged cell.
