Week 38- Focal brain dysfunction: Stroke Flashcards
What is the main form of cerebral vessel control?
Local autoregulation play the major role
Very small role by Neural control
What are some autoregulation factors within cerebral vessels?
Metabolic:
rise in CO2, fall in pH and pO2 (similar to coronary control)
- Adenosine (ATP breakdown)
- K+ (from action potentials due to neuronal activity
Local:
vasoactive substances from astrocytes (NO)
How does cerebral blood flow change with Arterial pressure?
Is relatively steady (except for increases to about 60)
What allows the cerebral blood flow to remain steady?
Autoregulation reassures adequate CBF during fluctuations of (arterial pressure)
What is the mechanism of NO release by astrocytes?
Increased neuronal activity Increased glutamate release Glutamate uptake by astrocytes Astrocytes release NO NO drives local vasodilation and increase in blood flow
What is stroke?
Ischaemic event leading to lack of blood supply to the brain:
Deficit of Oxygen
Deficit of glucose
Lack of waste removal
What is the two major types of stroke?
Ischaemic (80%) –> interrupted blood flow in a cerebral vessel
Haemorrhagic (20%) –> bleeding into brain tissue out of a cerebral vessel
What is blood supply so important to the brain?
No storage of crucial glucose and oxygen in the brain –> needs constant flow
What is a major cause of ischaemic stroke?
Embolism –> thrombus from other region of the body and travels to the brain
What side of the heart results in more thrombi and emboli from stroke?
Left side
What cardiovascular abnormalities may cause ischaemic stroke?
Intracranial atherosclerosis Penetrating artery disease Carotid plaque with arteriogenic emboli Flow reducing carotid stenosis Aortic arch plaque Cardiogenic emboli
How can causes of haemorrhagic stroke be described in two categories?
Increased pressure
OR
Decreased strength of the vessel
What cardiovascular abnormalities may cause haemorrhagic stroke?
Hypertension Aneurysms Arteriovenous malfunctions Head injury Blood dyscrasias -->is a nonspecific term that refers to a disease or disorder, especially of theblood.
What happens in the brain tissue after stroke at time points: 30s, 1min, 5min, 7mins?
30 seconds –> metabolism alters and slows
1 minutes –> neurons stop functioning
5 minutes –> anoxia leads to the start of infarction:
- Vasodilation and blood stasis - Oedema - Necrosis --> softening, liquefaction, tissue removal
7 minutes –> excitotoxic process begins to kill neurons
What is the cellular mechanism behind excitotoxic lesions?
Glucose/ O2 shortage gives two sequences of events via Loss of ATP and excess lactic acid
1. Loss of ATP --> Sodium potassium pumps stop functioning - K+ escapes, Na+ enters and the cells depolarise - Ca2+ released from intracellular stores AND calcium enters the cell via voltage- gated channels - Ca2+ overload - Calcium activates proteolytic and lipolytic enzymes, water also enters into the cells (following Ca2+) AND neurotransmitter Glutamate release - Autolysis via activated proteins begins --> Cell swells and rupture from water excess 2. Lactic acid increase --> fall in pH
What is the effect of neurotransmitter release (glutamate) during excitotoxic shock?
Glutamate released by calcium overload feeds back to increase calcium through voltage gated and ligand gated calcium channels
What is the two key anatomies of a stroke region?
Core –> dead, infarcted brain tissue
Penumbra –> threatened, potentially salvageable tissue surrounding the infarct core soon after stroke
What are some signs and symptoms of stroke?
Sudden onset
Combination of sensory, motor and cognitive deficits
Commonly:
- Loss of sensation and numbness in one side of the body
- Hemiplegia (same side as sensory disorder) and muscle weakness of the face (droop)
- Initial reduction of muscle tone –> replaced by muscle rigidity/spasticity and hyperreflexia on the same side
Why do clinical signs appear on the opposite side of the body compared to the side of the brain with the stroke?
There is cross-over of both sensory and motor pathways in the brain
What determines clinical signs in stroke?
Location and extent of the stroke (core and penumbra)
What are some signs of stroke occurring in the brainstem?
Altered smell, taste, hearing or vision
Decreased sensation on the face
Ptosis (drooping eyelids) and weak ocular muscles
Facial muscle weakness (cant smile)
Weakness in tongue
Decreased reflexes (swallowing, pupils to light)
Possibly altered respiration
What are some signs of stroke affecting the cerebellum?
Altered equilibrium (not sitting/standing symmetrical) Altered coordination of movements
What time points would CT and MRI show stroke?
CT–> no significant changes in first 24hours
MRI–> can see as early as 15mins post stroke
Why is CT used in ED for suspected stroke?
To check for haemorrhage NOT for signs of stroke
–> if no haemorrhage –> thrombolytics etc can be given to dissolve clot and return blood flow
What are the main treatments and managements of strokes (mainly embolic)?
Thrombolysis
Thrombectomy
Body cooling
What is CSF?
A filtrate from the blood
How often is CSF replaced?
Totally replaced in 5-7 hours
What path does CSF flow in the body?
Chorioid plexus of the lateral ventricles 3rd ventricle Cerebral aqueduct 4th ventricle Foramina Magendi and Luska Subarachnoid space Arachnoid granulations Sagittal sinus
What is the primary roles of CSF?
Cushioning
Bringing nutrients and taking waste away
What produces CSF?
Secreted by the chorioid plexus –> a network of ependymocytes located in the lateral ventricles
How does the ependymocytes drive water from the blood for CSF?
Transport of Na+ Cl- and HCO3 from the plasma to the ventricle creating an osmotic gradient to drive H2O
What is normally present and not present in CSF?
Present –> Clear H2O, Glucose, small amount of protein
Not present –> WBC, large amounts of protein
What is elevated protein in CSF a sign of?
Damage to the blood-brain barrier
What is cranial volume?
Volume of the brain space –> inside the skull
= volume of brain + volume of blood + volume of CSF
–> its value is constant