Week 36- Lower Limb and Soft Tissue Flashcards
What are some haemodynamic changes in response to exercise?
- Increase –> HR, SV, CO
- Redistributed blood flow
- Blood mobilised from venous pools
What are some respiratory changes in response to exercise?
- Increase –> Tidal volume, respiratory rate and minute ventilation
- Bronchodilation
What is the change in the blood in response to exercise and why?
Blood glucose increased –> energy required by muscles
What is some renal changes in response to exercise?
Reduction in renal blood flow and GFR
Increased reabsorption of NaCl and water
What is some thermoregulation undertaken during exercise?
Increased dissipation of heat via sweat evaporation
What is Stroke volume? SV
Blood volume ejected from each ventricle (its equal for each) during a single cardiac contraction
At rest 60-80mL –> exercise can boost to 180mL
What is Cardiac output and its formula?
The amount of blood pumped per minute:
CO = HR x SV
Is heart rate and stroke volume altered by physical health training by athletes etc?
Stroke volume increases a lot with training
HR –> returns to rest quicker
How does muscle contraction shift venous pooled blood to the heart?
Contraction mechanically pushes blood through the veins
How does the increase in venous return lead to an increase in CO?
- Increase venous return
- Increased myocardial contractibility (frank starling law)
- Rise in stroke volume
- Rise in cardiac output
What can predispose someone to DVT?
Long periods of inactivity in sitting position –> slow blood flow –> pooling –> thrombus formation
How does blood pressure rise from rest during aerobic exercise vs heavy load exercise?
Aerobic –> moderate increase
Heavy load – large increase
What is the equation for blood pressure?
BP = CO x TPR (total peripheral resistance)
What is the exercise pressor reflex?
Pressor reflectory response triggered by contracting muscles. Can be triggered by both mechanically and metabolically sensitive muscle afferents.
What is the result of the mechanoreflex and metaboreflex within the exercise pressor reflex?
Mechano –> immediate rise of Arterial Pressure initiated by muscle deformation or stretch
Metabo –> delayed rise in Arterial Pressure following stimulation of muscle chemoreceptors by metabolites (eg lactate, K+, ATP, H+, prostaglandins)
What are the two key baroreflex receptors?
Glossopharyngeal nerve and vagus nerve
How does an increase in aterial pressure drive the baroreflex?
- AP rise
- Glossopharyngeal and vagus signalling
- Brainstem:
- activation of cardiac vagal neurons
- inhibition of cardiac and vascular sympathetic neurons - Increase in cardiac vagal activity and decrease in cardiac and vascular sympathetic activity.
- More vagus = more Acetylcholine release to cardiac sites
Less sympathetic means less NA release to cardiac sites and vascular sites
- HR falls and vasodilation occurs
- CO declines
- AP falls
What is the mechanism of the bainbridge (aterial) reflex?
- Increase in venus return (increased CVP and aterial pressure)
- Activation of atrial and pulmonary vein stretch receptors
- Signal sent to cardioregulatory and vasomotor centres of the medulla oblongata
- Cardiac vagus signal decreased
- Cardiac sympathetic signal increased - HR increases
What are some intrinsic autoregulatory mechanisms in exercising muscle?
- Exercise = increase in energy demand + increase in metabolite production
- Reduced pO2
- Decreased ATP
- Increased lactate
- Increased pCO2
- Reduced pH - All these factors result in local vasodilation
What is the main factor for autoregulation in coronary blood flow?
Hypoxia –> but other factors include CO2 increase and fall in pH
What is the mechanism driven by hypoxia in cardiac myocytes?
- Hypoxia
- Breakdown of ATP in cardiac myocytes
- Increased adenosine
- Adenosine activates A2 receptors on vascular smooth muscle
- Activation of K(ATP) channels
- Hyperpolarisation
- Smooth muscle relaxation
- Vasodilation
What is the equation for minute ventilation?
VE (total gas entering the lung per minute = TV (tidal volume = normal volume of air displaced in one breath) x FR (resp rate)
How does blood pH and pCO2 affect alveolar ventilation?
pCO2 has a much greater increase
Why must renal adjustments be made during exercise?
Exercising causes a rise in BP and sweating –> without renal compensation this increased fluid loss would lead to dehydration