Student made multichoice Flashcards
- Which type of thalassaemia is considered the most severe?
a. Type 1
b. Beta
c. Thalassaemia Major
d. Haemoglobin H disease
c. Thalassaemia Major
- Thalassaemia is NOT common in which of the following ethnicities?
a. Mediterranean
b. Caucasian
c. Southern Asian
d. African
b. Caucasian
- Haemochromatosis can be identified on an FBC by which of the following findings?
a. Low HbA1C
b. High TSH
c. HFE gene mutation
d. High Serum Ferritin
d. High Serum Ferritin
- Which of the following clotting factors is part of the intrinsic pathway?
a. Xa
b. Xia
c. VIIa
d. XIIIa
b. Xia
- What is the action of Transglutaminase (Factor XIIIa) on Fibrin?
a. Makes fibrinogen insoluble
b. Polymerises fibrin chains
c. Dissolves fibrin polymers
d. Cross-links fibrin chains
d. Cross-links fibrin chains
- Which of the following physiological processes is NOT responsible for the localisation of a clot?
a. Thrombin absorption by fibrin
b. Vasoconstriction causing concentration of clotting factors
c. Blood flow dilution of Factor Xa
d. Plasminogen binding to clots
b. Vasoconstriction causing concentration of clotting factors
- Which of the following bones contains red bone marrow?
a. Distal femoral head
b. Skull
c. Proximal phalanx
d. Proximal humeral head
b. Skull
- Which of the following cells is a precursor for platelets?
a. Megakaryocyte-erythroid progenitor
b. Common myeloid progenitor
c. Myeloblast
d. Pronormoblast
a. Megakaryocyte-erythroid progenitor
- A patient has suffered severe burns and as a result requires urgent plasma transfusion. Her blood type was found to be A+. As a result, she can receive plasma from a blood donor with blood type:
a. A+ only
b. A and AB types only
c. O and A types only
d. O and B types only
b. A and AB types only
- Which of the following is a characteristic of a primary lymphocytosis?
a. Self-limiting
b. Normalises after cessation of inflammatory stimulus
c. No clinical symptoms
d. Chronic
d. Chronic
- Which of the following is typically a distinguishing symptom of leukaemia from lymphoma?
a. Bone pain
b. Fatigue
c. Enlargement of lymph nodes
d. Frequent infection
a. Bone pain
- Which haemostatic drug can be counteracted by ingestion of Vitamin K?
a. Heparin
b. Rivaroxaban
c. Warfarin
d. Aspirin
c. Warfarin
- Which of the following medication classes doesn’t affect platelets directly?
a. Thrombin Inhibitors
b. COX Inhibitors
c. P2Y12 Receptor Antagonists
d. GPIIb-IIIa Receptor Antagonists
a. Thrombin Inhibitors
- What is the mechanism of action of Alkylating agent antineoplastic treatment?
a. Inactivation of growth factors by targeting cell-surface receptors
b. Binding to the kinase active site to cause apoptosis
c. Cross-chain linking of DNA, causing G2 stage block and apoptosis
d. Iimitation of nucleotides disrupting the DNA/RNA synthesis pathway
c. Cross-chain linking of DNA, causing G2 stage block and apoptosis
- Which of the following factors is not part of Virchow’s Triad?
a. Increased platelet activity
b. Hypercoagulability
c. Damage to endothelial layer of vein
d. Changes to normal blood flow
a. Increased platelet activity
- Which of the following haemostatic factors is NOT useful in large vessels?
a. Blood vessel spasm
b. Initiation of the blood coagulation pathway
c. Fibrinolysis and re-establishment of vascular integrity
d. All of the above
d. All of the above
- Where does von Willebrand Factor bind to in the blood vessel?
a. Endothelial membrane
b. Endothelial smooth muscle
c. Collagen in basement membrane
d. Red blood cells
c. Collagen in basement membrane
- What platelet-released chemical induces vasospasm in blood vessels?
a. Calcium
b. Heparin
c. Noradrenaline
d. Von Willebrand Factor
a. Calcium
- Which of the following is not a complement pathway?
a. Histocompatible pathway
b. Lectin pathway
c. Classical pathway
d. Alternative pathway
a. Histocompatible pathway
- Which of the following is an appropriate definition of Opsonisation?
a. Clumping of pathogen to prevent spread
b. Coating of pathogen surface to increase internalisation
c. Prevention of pathogen binding with host cells
d. Activation of immune cells in the presence of the pathogen
b. Coating of pathogen surface to increase internalisation
- Which of the following myeloid cells has a role in the haemostatic process?
a. Macrophage
b. Eosinophil
c. Dendritic Cell
d. Basophil
d. Basophil
- Which of the following innate immune cells isn’t thought to be involved in the allergic response?
a. Eosinophil
b. Mast Cell
c. Basophil
d. Neutrophil
d. Neutrophil
- A mutation in which of the following genes would impact the ability of immune cells to function correctly?
a. HLA Locus
b. HFE Gene
c. TCR Locus
d. PSEN1 Gene
a. HLA Locus
- Which of the following cells is responsible for the mediation of Graft vs. Host disease?
a. Plasma Cell
b. Natural Killer Cell
c. Macrophage
d. Innate Lymphoid Cells
b. Natural Killer Cell
- Failure of the bone marrow to effectively negatively select B cells would result in which of the following pathologies?
a. Overly high affinity for a pathogen
b. Autoimmune-reactive B cells
c. Inhibition of isotope switching
d. Failure to produce antibodies
b. Autoimmune-reactive B cells
- Failure of the thymus to effectively positively select T cells would result in which of the following pathologies?
a. Somatic hypermutation
b. T cells that recognise multiple antigens
c. Cells with the inability to multiply
d. Cells that can’t bind to MHC
d. Cells that can’t bind to MHC
- Which of the following descriptor terms can be applied to psoriasis?
a. Scale
b. Macule
c. Papule
d. Nodule
a. Scale
- A 6-year-old child presents to the GP with fever, rhinitis, a chesty cough and an eruptive, itchy rash. This rash could be described as:
a. Lentigo
b. Atopic Dermatitis
c. Exanthem
d. Psoriasis
c. Exanthem
- A 28-year-old female patient presents to the GP. Upon examination, she has a rash on her face that spreads across each cheek and over the bridge of her nose. A rash of this type is most likely:
a. Autoimmune
b. Cancerous
c. Allergic
d. Infectious
a. Autoimmune (SLE) lupus
- Which of the following skin cancers is considered the most dangerous?
a. Malignant Melanoma
b. Squamous Cell Carcinoma
c. Superficial Basal Cell Carcinoma
d. Nodular Basal Cell Carcinoma
a. Malignant Melanoma
- The chemically reactive combination of a molecularly small drug and a large protein or peptide is known as a:
a. Self-peptide
b. Hapten
c. Complex
d. Leukotriene
b. Hapten
- David is a 54-year-old man who has had a heart transplant 8 hours ago. He is currently suffering from graft rejection, and immune cells are damaging his other heart tissue. This is an example of what type of hypersensitivity?
a. Type I
b. Type II
c. Type III
d. Type IV
d. Type IV
- A foreign chemical that can stimulate T cells without being processed by an APC is known as a:
a. Superantigen
b. Hapten
c. Cryoglobulin
d. Vimentin
a. Superantigen
- Which of the following conditions is NOT associated with a Group A streptococcal infection?
a. Scarlet Fever
b. Toxic Shock Syndrome
c. Guillain-Barre Syndrome
d. Rheumatic Fever
c. Guillain-Barre Syndrome
- Which of the following processes is NOT an example of peripheral tolerance?
a. Negative selection
b. Anergy
c. Deletion
d. Suppression
a. Negative selection
- Campylobacter is theorised to share a surface protein with Schwann cells, meaning that if a Campylobacter infection occurs, immune cells may also attack the nerves. This is an example of:
a. Altered Cytokine Activation
b. Bystander Activation
c. Molecular Mimicry
d. Sequestered Antigen Release
c. Molecular Mimicry
- Which of the following laboratory tests would NOT suggest a diagnosis of Rheumatoid Arthritis?
a. Elevated erythrocyte sedimentation rate
b. Antinuclear Antibody presence
c. Anti-cyclic citrullinated peptide antibody presence
d. Rheumatoid factor presence
b. Antinuclear Antibody presence
- DMARD medication can be described as
a. Immunosupressive therapy
b. Immunomodulatory therapy
c. All of the above
d. None of the above
c. All of the above
- Sue is a 58-year-old woman suffering from Osteoporosis. Her doctor prescribes her medication for this. Sue, being a curious person, asks her doctor how the medication works. The doctor says that when this medication kills the cells that eat away at her bone. From this description, Sue has likely been prescribed a:
a. Recombinant monoclonal antibody
b. Selective Oestrogen Receptor Modulator
c. Hormone Replacement Therapy
d. Bisphosphonate
d. Bisphosphonate
- The cell responsible for the maintenance and restructuring of connective tissue is known as:
a. Fibroblast
b. Wandering Cell
c. Mesenchymal Cell
d. Connective Progenitor Cell
a. Fibroblast