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Pharmacology > Week 3 Immunity Drugs > Flashcards

Week 3 Immunity Drugs Flashcards

1
Q

Immune stimulants do what?

A

energize and assist immune system to fight specific pathogens or cancer cells

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2
Q

Immune suppressants do what?

A

Block and drepress immune system to prevent transplant rejection or severe tissue damage or autoimmune disease

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3
Q

Immune suppressant classes

A
  • T/B cell suppressors
  • Monoclonal antibodies
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4
Q

Immunes suppressant prototypes

A

Cyclosporine and bevacizumab

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5
Q

Immune stimulant classes

A
  • interferon
  • colony-stimulating factors
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6
Q

Immune stimulant prototypes

A
  • interferon alpha 2b
  • fligrastim
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7
Q

Interferon prototype drug

A

Interferon alpha 2b

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8
Q

Colony stimulating factor prototype drug

A

fligrastin

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9
Q

T/B cell suppressants prototype drug

A

cyclosporin

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10
Q

Monoclonal antibodies prototype drug

A

Bevacizumab

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11
Q

Therapeutic action of Interferons

A
  • Inhibits the growth of the tumor cells and enhances immune response
  • inhibits tumor growth and replication
  • enhances inflammatory reaction
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12
Q

Therapeutic action of colony-stimulating factor

A
  • increase production of neutrophils in bone marrow
  • increase WBC production
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13
Q

Therapeutic action of T/ B cell suppressants

A
  • block antibody production by B cells
  • inhibit suppressor and helper T cells
  • reversibly inhibits immunocompetent lymphocytes, t helper cells, suppressor cells, and lymphokine production
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14
Q

Therapeutic action of Monoclonal antibodies

A
  • inhibits vascular endothelial growth factor leading to decreased angiogenesis and cell proliferation
  • work against malignant or viral cell sites
  • specific key to specific receptor types
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15
Q

Indication for Monoclonal antibodies

A
  • metastic colorectal cancer, non-squamous cell, non small cell lung cancer, glioblastoma, renal cell carcinoma, cervical cancer, ovarian cancer, COVID 19
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16
Q

Indication for T/B cell suppressant

A
  • prophylaxis for solid organ rejection
  • treatment for chronic rejection
  • treatment for RA and psoriasis
17
Q

Indication for colony-stimulating factor

A
  • reduce infections in pts w/ bone marrow suppression
  • neutrophil recovery w/ myelosuppressive chemotherapy, leukemia, bone marrow transplants
18
Q

Indication for Interferons

A
  • hairy cell leukemia, chronic hep B/C, malignant melanomia,
19
Q

Pharmacokinetics for interferons

A
  • IM, IV, SubQ
  • rapid onset, peak 3-8hr
  • broken down in kidney
20
Q

Pharmacokinetics for Colony- stimulating factor

A
  • IV, SubQ
  • Varying peak, onset and duration
  • metabolism and excreted unknown
21
Q

Pharmacokinetics for T/B cell suppressants

A
  • varies by med; GI or IV
  • metabolized by liver and excreted by stool or urine
22
Q

Pharmacokinetics for monoclonal antibodies

A
  • given IM, IV, SubQ
  • GI rapidly breaks down protein
  • processed like naturally occurring antibodies
23
Q

Adverse Effects in Monoclonal Antibodies

A
  • thrombotic events, GI perforation
  • third spacing of fluids and shock!
  • flu-like symptoms
24
Q

Adverse Effects of T/B cell suppressants

A

-increased risk of infection
- increased risk of development of neoplasms
- possible pulmonary edema

25
Adverse Effects of colony-stimulating factor
GI> n/v/d, anorexia - increased activity bone marrow> bone pain
26
Adverse Effects in Interferons
- flu-like symptoms - lethargy, n/v, dizziness
27
Contradictions of interferons
- DO NOT USE DURING PREGNANCY - CNS dysfunction - teratogenic in animals> harmful to child
28
Contradictions of Colony-stimulating factor
- Avoid neonates - caution in pregnancy adn lactation
29
Contradictions of T/B cell suppressants
- allergy to drug - cautions w/ hepatic/ renal impairment - known neoplasms> potential spread
30
Contradictions of Monoclonal antibodies
- fever> treat before beginning therapy - fluid overload
31
Drug to drug interaction of Monoclonal antibodies
- caution w/ other immunosuppressant drugs
32
Drug-to-drug interaction of T/B cell suppressants
- MUST avoid grapefruit juice - increased risk of toxicity w/ hepatotoxic or nephrotoxic drugs
33
Drug to drug interaction of Colony-stimulating factor
- increased myeloproliferation effects of some when combined with corticosteroids and lithium - not given w/ active chemo or radiation
34
Drug to drug interaction of Interferons
- NO drug interactions
35
Nursing Considerations for Interferons
- monitor CBC> WBC - DO NOT TAKE WHILE PREGNANT - CARDIAC FUNCTION TESTS - liver/ renal function tests
36
Nursing Considerations for Colony stimulating factor
- monitor CBC> WBC - DO NOT TAKE WHILE PREGNANT - cardiac function - liver/ renal function tests
37
Nursing Considerations for T/B cell suppressants
- Assess lung sounds - monitor temp/ signs of infection - monitor function of transplanted organ - strict aseptic technique
38
Nursing Considerations for Monoclonal antibodies
- Assess lung sounds - monitor temp/ signs of infection - monitor function of transplanted organ - strict aseptic technique

Pharmacology (17 decks)

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