WEEK 3: HOST-MICRO CONTROL Flashcards

1
Q

Biological relationship between two or more organisms where both benefit from one another.

A

Symbiosis (Mutualism)

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2
Q

Organism benefits but there is no beneficial or harmful effects to the host

A

Commensalism

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3
Q

The microbe benefit at the expense of the
other (host).

A

Parasitism

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4
Q

Commonly found in body sites of healthy persons.

A

Microbial Flora

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5
Q

Microorganisms that colonize an area for months or years.

A

Resident microbial flora

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6
Q

➢ Present at a site temporarily, eliminated by host immune defense / competition with
resident flora.
➢ Carrier state may be acute (S. aureus) or
chronic (S. typhi)

A

Transient microbial flora

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7
Q

E.g: Diptheroids in moist areas

A

Nutritional and Environmental factors

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8
Q

E.g: P. acnes in hair follicles

A

Resistance to bile, lysozymes or fatty acids

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9
Q

E.g: Lactobacillusin Female genital tract

A

pH

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10
Q

E.g: Obligate anaerobes in the colon

A

Oxidation-reduction potential

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11
Q

Mouth, nasopharynx, oropharynx
and larynx

A

Upper Respiratory Tract

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12
Q

Viridans Strep. and Gram (-) anaerobes

A

Mouth

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13
Q

Diplococci and Diphtheroids * Oropharynx → Gram (-) anaerobes and Diphtheroids

A

Nose and Nasopharynx

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14
Q

Anaerobes makes up 90% of the microbial
flora
➢ Esophagus, stomach, small
intestine, and colon

A

Respiratory Tract

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15
Q

➢ G(+) staph and Enterococcus
➢ Anaerobic G(+) cocci and spore forming bacilli
➢ Enterobacteriaceae

A

Respiratory Tract

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16
Q

Example:
➢ Lactobacillus acidophilus
➢ Anaerobic Sporeformers
➢ G(+) cocci / Diphtheroids

A

Gastrointestinal Tract

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17
Q

Gastrointestinal Tract

A

➢ Sites – urethra and vagina
➢ Sterile – Kidneys, bladder and fallopian
tubes

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18
Q

➢ Activates or primes the immune system (e.g. cell mediated immunity)
➢ Blocks the colonization of extraneous pathogens.

A

Microbial Flora a in the Host Defense Against Infectious Disease

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19
Q

➢ Cause disease when their habitat is damaged, disturbed or changed by trauma or;
➢ When the host’s immune system is weakened or compromised

A

Microbial Flora in the Pathogenesis Infectious Disease

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20
Q

Is the ability of a microbe to produce disease in a susceptible individual.

A

Pathogenicity

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21
Q

➢ Organisms recognize to cause disease in healthy immune-competent individuals.
➢ B. anthracis and Y. pestis

A

True Pathogen

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22
Q

➢ Organisms that cause opportunistic or iatrogenic infections (medical treatment or procedures)
➢ H. influenzae and S. epidermidis

A

Opportunistic Pathogen

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23
Q

Is the relative ability of a microorganism to cause disease or the degree of pathogenicity

A

Virulence

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24
Q

➢ Allows pathogens to evade or overcome host defenses and cause disease
➢ E.g. Fimbriae, Capsules and Toxins

A

Microbial Virulence Factors

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type of interference in staphylococcus and streptococcus
kill phagocyte
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induces lysosomal discharge
leucocidin and streptolysin
27
type of interference in H. influenza, P. aeruginosa, E. coli, and S. typhi
resist phagocytosis
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mechanism of E. coli
O and K antigen
28
mechanism of H. influenza
polysaccharide capsule
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mechanism of P. aeruginosa
surface slime (polysaccharide)
28
e.g. Chlamydia, Mycobacterium, Brucella and Listeria
Ability to Survive Intracellularly
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➢ Cell surface structures that mediate attachment ➢ E.g. fimbriae and surface polysaccharides
Adhesins
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mechanism of S typhi
Vi antigen
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▪ e.g. lactoferrin – meningococci; IgA protease – H. influenzae and Neisseria)
Ability to avoid or overcome local factors
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these two contribute to low pH.
Microbial flora and Sebaceous gland
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▪ e.g. Salmonella
Ability to Proliferate (Dissemination)
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Poisonous substances produced by organisms that interact with host cells, disrupting normal metabolism and causing harm.
Toxins
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➢ Secreted by the organism into the extracellular environment ➢ Toxin gene is commonly encoded by phages, plasmids or transposons.
Exotoxins
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➢ A constituent Lipid A of the outer membrane of gram (-) bacteria ➢ Released upon lysis of the organism
Endotoxins
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presents as mechanical barrier
Skin epithelium
33
(hydrolyzes peptidoglycan layer of bacterial cell walls) and β-lysin in serum and/or body fluids
Complement, Lysozyme
34
cellular protein that inhibit proliferation of viruses
Interferons
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I. Desquamation of skin surfaces. II. Flushing of tears and urine III. Mucus production of membrane lining the nasopharynx. IV. Sweeping of particles by Ciliary epithelium (trachea) V. Low pH of the stomach
Cleansing Mechanisms
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I. HCl in the stomach II. Secretory IgA of the mucosa III. Complement, Lysozyme (hydrolyzes peptidoglycan layer of bacterial cell walls) and β-lysin in serum and/or body fluids IV. Interferons - cellular protein that inhibit proliferation of viruses
Antimicrobial Substances
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I. Compete with pathogens for nutrients and space II. Produce bacteriocins(inhibit the growth of closely related bacteria) III. Production of metabolic byproducts that inhibits pathogens IV. Synthesis of vitamins and other essential nutrients
Indigenous Microbial Flora
37
- chemotaxis - attachment - ingestion - killing
Phagocytosis
38
enhanced phagocytosis by PMNs due to coating of bacterium with antibody or complement
Opsonization (opsonins)
39
migration of PMNs into area of infection
Chemotaxis
40
movement of PMNs from blood vessel into tissues (surveillance)
Diapedesis
41
I. Body’s response to injury or foreign body II. Hallmark is accumulation of phagocytic cells III. Leukocytes and other cells release mediators to cause erythema, edema and pus IV. Enzymes digest foreign particles, injured cell and cell debris
Inflammation
42
increase blood flow (R)
Redness
43
increase temperature of affected tissue (C)
Heat
44
vasodilation of blood vessels (T)
Swelling
45
tissue damage and pressure from increased (D) flow of fluid and cells
Pain
46
acts as mediator of infection
Blood Proteins
47
➢ Physical & Chemical barriers - skin and mucous membranes ➢ Blood Proteins - acts as mediator of infection ➢ Cellular Mechanisms - phagocytosis (neutrophils, macrophages, natural killer cells)
Innate or Natural Immunity
48
phagocytosis (neutrophils, macrophages, natural killer cells)
Cellular Mechanisms
49
after infection (natural)
Active
50
Vaccination-Abs dev’t
Active
50
Abs from mother to child
Passive (natural)
51
Anti-toxin/ Immune globulin ex. Anti-tetanus
Passive
51
what does humor mean in latin?
body fluid
52
able to remember each time it encounters a particular antigen *Anamnestic immune response (rapid increase in IgG Abs)
Immunologic memory
53
53
- intact skin - mucous membranes and their secretions - normal microbiota
first line of defense
54
- phagocytic white blood cells - inflammation - antimicrobial substances
second line of defense
54
- specialized lymphocytes: B cells and T cells - antibodies
third line of defense
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Routes of Transmission
A. Airborne Transmission B. Food and Water C. Close Contact D. Cuts and Bites E. Arthropods F. Zoonoses
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