Week 3: Cell Cycle Flashcards

1
Q

What is cell growth?

A

Increase in cell size (Hypertrophy)

Cell growth is distinct from proliferation.

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2
Q

What is proliferation?

A

Increase in cell number (Hyperplasia) by cell division occurring faster than cell death

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3
Q

What is the normal rate of cell division for frog embryo cells?

A

30 minutes

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4
Q

What are the two major events in the cell cycle?

A
  • S-phase (synthesis phase)
  • M-phase (mitotic phase)
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5
Q

What occurs during the S-phase of the cell cycle?

A

Chromosomes duplicate

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6
Q

What happens during the M-phase of the cell cycle?

A

Duplicated chromosomes segregate into daughter cells

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7
Q

What are the four phases of the cell cycle?

A
  • G1 phase
  • S phase
  • G2 phase
  • M phase
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8
Q

What is Interphase in the context of the cell cycle?

A

G1, S, and G2 phases combined

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9
Q

What occurs during Interphase?

A
  • Growth
  • Performing normal cellular functions
  • Duplication of protein content
  • Duplication of RNA content
  • Duplication of chromatin
  • Duplication of organelles
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10
Q

What is the G0 phase?

A

A resting state where most cells do not divide

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11
Q

What is required for a cell to move from G0 to G1?

A

Stimulation by growth factors

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12
Q

What is MPF?

A

Mitosis-promoting factor, a complex of proteins that induces mitosis

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13
Q

What is the role of CDK in the cell cycle?

A

Master regulator of the cell cycle and a kinase enzyme that adds phosphate groups to amino acids in polypeptides

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14
Q

What are cyclins?

A

Regulatory subunits that undergo cycles of synthesis and degradation during the cell cycle

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15
Q

List the four classes of cyclins.

A
  • G1/S-cyclin (cyclin E)
  • S-cyclin (cyclin A)
  • M-cyclin (cyclin B)
  • G1-cyclin (cyclin D)
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16
Q

True or False: The cell cycle is free running in early embryos.

A

True

17
Q

What is the difference in cell cycle regulation between early embryos and somatic cells?

A

Early embryos have a free-running cell cycle, while somatic cells have a regulated cell cycle.

18
Q

During which phase do DNA levels double until cell division occurs?

A

S phase

19
Q

What happens to protein and RNA levels during cell division?

A

They will halve as the cell divides

20
Q

What role do growth factors play in the cell cycle?

A

They stimulate cells to enter the cell division cycle

21
Q

What is the significance of the Nobel Prize awarded in 2001 related to the cell cycle?

A

It was awarded for discoveries of key regulators of the cell cycle.

22
Q

Fill in the blank: The G1 phase occurs ______ the S phase.

A

before