Week 2 formulas

Question 1

=.6*body wt (kg)

Answer 1

Total body water (TBW) equation

Question 2

=.4*body wt (kg)

Answer 2

intracellular fluids (ICF) equation

Question 3

=.2* body wt (kg)

Answer 3

Extracellular fluids (ECF) equation

Question 4

=2/3TBW

Answer 4

ICF equation as function of TBW

Question 5

=1/3TBW

Answer 5

ECF equation as function of TBW

Question 6

=.75ECF

Answer 6

Interstitial fluid (ISF) equation

Question 7

.25ECF

Answer 7

Plasma equation

Question 8

=amount of indicator (mg)/ [] of indicator (mg/ml)

Answer 8

Volume (ml) equation

Question 9

=ECF-Plasma

Answer 9

ISF equation as function of ECF

Question 10

=ISF+Plasma

Answer 10

ECF

Question 11

=ECF-ISF

Answer 11

Plasma

Question 12

=amount of indicator (mg)/avg. [] in arterial blood (mg/ml)

Answer 12

Flow in time of 1st passage equation

Question 13

=total amount of drug in body (mg)/plasma [] of drug (mg/ml)

Answer 13

Volume of distribution (Vd) formula

Question 14

=6.022*10^23 molecules

Answer 14

1 mole

Question 15

=2 x [Na+] (meq/L)+ ([gluc] (mg/dL)/18) + ([BUN] (mg/dL)/2.8)

Answer 15

Plasma osmolality (Posm) (milliosmolar (mOsm))

Question 16

J=DA(C1-C2)/dX

J=flow of solute (flux) (mol/cm^2 s)

D= diffusion coefficient (cm^2/s)

A=cross-sectional area (cm^2)

dX= thickness (cm)

C1, C2= concentrations (mol/cm^3)

Answer 16

Fick’s first law of diffusion

Question 17

=C (membrane) / C(aqueous)

C= [] (mol/L)

Answer 17

Partition coefficient (ß) formula

Question 18

J=(D x ß x A (C1-C2)) / dX

J=flow of solute (flux) (mol/cm^2 s)

D= diffusion coefficient (cm^2/s)

A=cross-sectional area (cm^2)

dX= thickness (cm)

C1, C2= concentrations (mol/cm^3)

Answer 18

Fick’s first law of diffusion with partition coefficient (ß)

Question 19

J=PA (C1-C2)

J=flow of solute (flux) (mol/cm^2 s)

P= permeability coefficient (cm/s)

A=cross-sectional area (cm^2)

C1, C2= concentrations (mol/cm^3)

Answer 19

Fick’s law for diffusion of an uncharged solute

Question 20

J = Kf[(Pc-Pi) – σ(πc-πi)]

Kf = Capillary Filtration Coefficient & includes the capillariy conductivity x area
σ = reflection coefficient for plasma proteins (if impermeant = 1; if freely permeable = 0)

Answer 20

Starling equation