Week 2: Antibodies

Question 1

Low concentration in the blood
Primarily found on the surface of B lymphocytes
Function as one type of B cell antigen receptor

Answer 1

Immunoglobulin D (IgD)

Question 2

Least concentrated Ig class in circulation
Binds to surface of mast cells and basophils
Defender against parasites (activate eosinophils)
Mediator of many common allergic responses
Most powerful activator if inflammation response
10x more in atopic individuals

Answer 2

Immunoglobulin E (IgE)

Question 3

Largest of the immunoglobulins
Pentamer stabilized by a J-chain
First antibody produced during the primary response to an antigen
Synthesized during fetal life
Also produced following exposure to T-independent Antigen

Answer 3

Immunoglobulin M (IgM)

Question 4

Most abundant class (80%-85% of circulating Abs in adults)
Transported across the placenta*
Contributes to natural passive immunity in neonates
Four classes

Answer 4

Immunoglobulin G (IgG)

Question 5

Adaptive immune system present in tears
Dominant Ig class in secretory system

Answer 5

Immunoglobulin A (IgA)

Question 6

3 Indirect antibody functions

Answer 6

Complement Activation
Opsonization
Antibody dependent cell-mediated cytotoxicity

Question 7

3 DIRECT antibody functions

Answer 7

Neutralization
Agglutination
Precipitation

Question 8

Number of binding sites of IgG

Answer 8

2

Question 9

Number of Binding sites on IgD

Answer 9

2

Question 10

Number of Binding sites on IgE

Answer 10

2

Question 11

Number of Binding sites on IgA

Answer 11

4

Question 12

Number of Binding sites on IgM

Answer 12

theoretically 10, likely 5

Question 13

What immunoglobulins have 2 binding sites?

Answer 13

IgE, IgD, IgG

Question 14

What immunoglobulins have 4 binding site?

Answer 14

IgA

Question 15

What immunoglobulins have 5-10 binding sites?

Answer 15

IgM