Hematology 1 Flashcards

1
Q

Where are the 4 main sites of production of red blood cells in adults?

A

Vertebrae
Pelvis
Sternum
Ribs

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2
Q

Lifespan of RBC

A

90-120 days

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3
Q

What are RBCs removed by?

A

Mononuclear Phagocyte system
(Spleen, liver, lymph nodes)

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4
Q

Describe the process of erythropoiesis

A

RBC production

Peritubular cells of the kidney produces erythropoietin.
Erythropoietin stimulates RBC production in bone marrow.
Process takes about 4 days.

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5
Q

What things are required for blood cells to grow properly?

A

Iron
Proteins
Vitamins (B12, Folate)

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6
Q

A vitamin deficiency of B12 and Folate would lead to what?

A

Impaired DNA synthesis in RBCs

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7
Q

What outcome of blood would an iron and protein deficiency cause?

A

Reduced ability to carry O2

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8
Q

What does hematocrit measure?

A

Percent of blood that are RBCs

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8
Q

What does hematocrit measure?

A

Percent of blood that are RBCs

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9
Q

Normal hematocrit percentage for males

A

42-50%

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10
Q

Normal hematocrit percentage for females

A

39-48%

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11
Q

Reduced levels of RBC

A

Anemia

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11
Q

Reduced levels of RBC

A

Anemia

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12
Q

Anemic levels for males

A

<42% hematocrit
Hb <13.0g/100mL

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13
Q

Anemic levels for females

A

<39% hematocrit
Hb <12.0g/100mL

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14
Q

What is the most common cause of anemia?

A

Iron deficiency

15
Q

What percent of Americans have anemia?

A

5.6%

16
Q

Symptoms of Anemia

A

Weakness
Tachycardia
Fatigue
Dyspnea
Palpitations
Angina
Pallor
Myelin Degeneration

17
Q

What are the 3 main ways of getting anemia?

A

1) Reduced RBC production
2) Excessive blood loss/hemorrhage
3) Increased RBC destruction

18
Q

How does lead poisoning cause anemia?

A

Inhibits heme and globin synthesis of RBCs

19
Q

Who is at higher risk of lead poisoning?

A

Children

20
Q

Early Signs and symptoms of lead poisoning

A

Pallor
Abdominal pain
irritability

21
Q

Late signs and symptoms of lead poisoning

A

Lethargy
Anorexia
Ataxia
Slurred speech, convulsions

22
Q

How do you treat lead poisoning?

A

Chelation
Remove lead source