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BMS200 final exam > week 2 > Flashcards

week 2 Flashcards

1
Q

B2 (riboflavin) coenzymes

A

FAD and FMN

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2
Q

B3 Niacin coenzymes

A

NAD+ and NADP+

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3
Q

B1 thiamin coenyzme

A

TDP/TPP

use phosphatase to make the coenzyme

thiamine pyrophosphokinase to make into coenzyme

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4
Q

anti thiamine factors causing b1 deficiency

A

sulphur dioxide
thiaminases
polyphenols

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5
Q

b1 defieincy affects CNS

A

wenicke Korsakoff syndrome

wet beriberi - cardiovascular sysstem

dry beriberi- CNS

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6
Q

b1 testing via

A

transketolase activity

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7
Q

riboflavin B2 into FAD and FMN

A

metabolize riboflavin to make coenzyme: FAD synthetase and flavokinase

absorp into b2: FAD pyrophosphates and FMN phosphatase

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8
Q

b2 and b3 help to regenerate which antioxidant

A

glutathione

via fadh and nad

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9
Q

b2 and neurotransmitter metabolism

A

AMINES; dopamine, NE, E

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10
Q

test b2 defieincy

A

glutathione reductase

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11
Q

b3 name

A

nicotinic acid or nicotiamdie

nicotinamide better supplement than the acid bc side effects (i.e. skin flushing)

coenzyme: NADH NADPH

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12
Q

corn and niacin bound to other things effects absorption

A

decrease

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13
Q

nicotine acid cause niacin flush via

A

vasodilatory prostaglandin release via cycylooxygenase

NSAIDs inhibit COX

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14
Q

nicotinic acid (b3) does what to clots

A

enhanced fibrinolysis

  • Actions on plasmin (increases) and fibrinogen (decreases)

dissolve clots

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15
Q

nicotinic acid effect on fats

A

Decreases circulating VDLD/LDL and increases HDL

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16
Q

symptoms of niacin B3 deficiency

A

Pellagra: dementia, dermatitis, diarrhea, death

17
Q

vitamin B5 (patothenic acid)

A

coenzyme A

i..e acetyl coa, succinyl coa, fatty acyl coa

18
Q

vitamin B6 (pyrixdox -al, ine, amine) for what rxns

A

transamination

amino acids and alpha ketoacids

pyruvate –> alanine
oxaloacetate –> aspartate
alpha ketoglutarate –> glutamate

other types of reactions, including:
▪ Trans- and de- sulfhydration ▪ Decarboxylation

19
Q

forms of B6 pyridox-

A

6 forms of vitamins

20
Q

coenzyme of B6

A

PLP pyridoxal phosphate

21
Q

b6 helps to make b3 (NAD+ coenyme) from the amino acid

A

tryptophan

22
Q

b6 and neurotrasnmistter

A

tryptophan –> GABA
tyrosine –> dopamine
glutamate –> GABA

23
Q

how does b6 make anti inflammatory prostaglandins

A

via turning linoleic acid to gamma linoleum acid

24
Q

b6 help with CVD risk by

A

turning homocysteine into cysteine

25
Q

test for B6

A

tryptophan load test

if deficient have high levels of xanthurenic acid (bc need PLP to continue rxn)

26
Q

b7 biotin coenzyme

A

lysine + CO2

to absorb need to remove carboxylase enzyme

does carboxylation rxn

27
Q

folate B9 coezynme

A

THF (glutamates + A H’s + 1C) tetrahydrofolate

28
Q

THF helps make

A

purine and pyrimidine (DNA)

deficincet could be megaloblastic anemia, spina bifida, cancer

29
Q

whew is b9 folate stored

A

liver trapped as polyGlu then transported via blood as MonoGLu

30
Q

b9 helps with which amino acids

A

methionine from homocysteine

with b12 too

31
Q

methyl folate trap from what vitamin deficiency

A

b12

32
Q

methyl folate made from

A

It is made from methyleneTHF
(MTHF) via the MTHFR enzyme

need b12

33
Q

folate b9 correlates with

A

dopamine and serotonin

34
Q

b12 cobalamin coenzymes

A

methylcobalmin (for methyl rxn) (methyl folate to homocysteine) (make methionine and regenerate THF)

adenosylcobalamin (for succinyl to propionyl coa)

35
Q

b12 in stomach

A

pepsin and Hcl release it from food

carried by r proteins

intrinsic factor picks it up from r protein and brings down to ileum for absorption

36
Q

b12 absorption

A

B12-IF-R via receptor-mediated endocytosis

37
Q

b12 deficiency from

A

hypochondria (HCL low) or Intrinsic factor deficiency

can cause megaloblastic anemia/ pernicious anemia

38
Q

b12 deficient test

A

Homocysteine or
▪ Methylmalonic acid

would be increase in both if deficient

BMS200 final exam (14 decks)

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