Week 10 - Mechanisms for Taste Sensation of Cabonation Flashcards
What 3 things does the chemical reaction of carbon dioxide give rise to?
- carbonates
- bicarbonates
- carbonic acid
the process of carbon dioxide dissolving in a liquid
carbonation
Carbonation is the water-mediated replacement of ____ minerals by ____ minerals in the Earth’s (or even Mars’) crust.
silicate
carbonate
True or false: Carbonation is a slow process
True
What is carbonation of concrete associated with?
loss of alkalinity of pore solution
a process by which carbon dioxide in the ambient air penetrates the concrete and reacts with the hydroxides, such as calcium hydroxide to form carbonates
carbonation
In the reaction between CO2 and calcium hydroxide, what is formed?
calcium carbonate
What does carbonation do to the alkalinity which protects the reinforcement bar in concrete?
reduces alkalinity
What does carbonation of concrete initiate?
deterioration of concrete
What is used to neutralize the alkalinity of the cement matrix in the concrete cover?
carbonic acid
What are the 4 sensory systems which respond to CO2?
- nociception
- olfaction
- chemoreception
- respiratory regulation
True or false: little is known about the cellular and molecular mechanisms of carbonation perception in the mouth
true
Who was the chemist that impregnated water with “fixed air” aka what is now known as carbon dioxide (CO2)
Joseph Priestley in 1772
What constitutes the single largest source of calories in the contemporary american diet?
soft drinks
Carbonation acts as a complex gustatory stimulus, stimulating _____, ____, and _____ taste qualities simultaneously.
sour
sweet
bitter
In mammals, carbonation elicits what two responses?
- somatosensory
- chemosensory
Describe CO2 sensing in caenorhabitidis elegans
Describe CO2 sensing in drosphila melanogaster
Describe CO2 sensing in mammals
What are specifically involved in the sensory detection of CO2?
carbonic anhydrases
enzymes that catalyze the interconversion of carbon dioxide with carbonic acid
carbonic anhydrases
What is the function of carbonic anydrase IV (Car4)?
extracellular glycosylphosphatidylinositol-anchored enzyme
What cells is carbonic anhydrase IV (Car4) expressed in?
acid sensing taste receptor cells (TRCs)
What did the genetic ablation of the Car4 locus result in?
major deficit in gustatory CO2 sensation
What do carbonic anhydrases reversibly catalyze the conversion of?
CO2 into biocarbonate ions and free protons
A secondary gustatory pathway for CO2 detection is mediated by subpopulations of what two neurons?
- bitter
- sweet
Carbonic anhydrase VII (Car7) is specifically expressed by what 3 TRCs?
- sweet
- bitter
- umami