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Hematology 2 PPT > Week 1 Part 2 > Flashcards

Week 1 Part 2 Flashcards

1
Q

What are the three layers of blood vessel?

A

Vascular intima (inner layer)
Vascular media (middle layer)
Vascular adventitia (outer layer)

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2
Q

provides interface between circulating blood throughout
the body

A

Vascular intima

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3
Q

its endothelial surface is usually inert to platelets and
coagulation (termed as non-thrombogenic surface)

A

Vascular intima

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4
Q

if the lining is disrupted, the injured vessel and its adjacent vessel constricts (vasoconstriction)

A

Vascular intima

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5
Q

Tunica intima
the innermost lining of blood vessels is a monolayer of
metabolically active _____________.

A

Endothelial cells

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6
Q

Anticoagulant Properties of Vascular Intima

A

Prostacyclin
Nitric Oxide
Tissue Factor Pathway Inhibitor
Thrombomodulin
Heparan sulfate

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7
Q

Platelet inhibitor

A

Prostacyclin (PGI2)

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8
Q

Vasodilator

A

Prostacyclin

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9
Q

Synthesized through the eicosanoid pathway

A

Prostacyclin

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10
Q

Induces smooth muscle relaxation (vasodilation)

A

Nitric oxide

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11
Q

Inhibits platelet activation

A

Nitric oxide

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12
Q

Promotes angiogenesis

A

Nitric oxide

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13
Q

Synthesized in ECs, vascular smooth muscle cells, neutrophils, and macrophages

A

Nitric oxide

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14
Q

Controls activation of the tissue factor pathway

A

Tissue Factor Pathway Inhibitor

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15
Q

Limits the activation of the TF:VIIa:Xa complex

A

Tissue Factor Pathway Inhibitor

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16
Q

Facilitated by the endothelial protein C receptor (EPCR)

A

Thrombomodulin

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17
Q

Serves as a cofactor in protein C activation when
bound to thrombin

A

Thrombomodulin

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18
Q

A glycosaminoglycan that enhances the activity of
antithrombin

A

Heparan sulfate

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19
Q

Present a smooth, contiguous surface

A

Vascular endothelium is composed of rhomboid cells

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20
Q

eicosanoid platelet inhibitor

A

Prostacyclin

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21
Q

A vascular “relaxing” factor

A

Nitric oxide

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22
Q

An anticoagulant that regulates thrombin generation

A

heparan sulfate

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23
Q

A regulator of the extrinsic pathway of coagulation

A

TFPI

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24
Q

An integral component of the protein C control system

A

EPCR

25
Q

A protein C coagulation control system activator

A

Thrombomodulin

26
Q

Activate fibrinolysis

A

TPA

27
Q

Procoagulant Properties of Vascular Intima

A

Vasoconstriction
Collagen
Von Willebrand Factor (vWF)
ADAMTS-13
P-selectin
Intercellular adhesion molecules (ICAMs)
Platelet endothelia cell adhesion molecules (PECAMs)
Smooth muscle cells and fibroblasts
Tissue Factor

28
Q

Induced by a harmful local stimulus (mechanical or chemical)

A

Vasoconstriction

29
Q

Produced by fibroblasts

A

Collage

30
Q

Binds and activates platelets

A

Collagen

31
Q

● Secreted by endothelial cells from its storage site called __________

A

Weibel-Palade bodies

32
Q

Primarily binds to platelet membrane receptor GPIb to
promote adhesion

A

Von willebrand factor

33
Q

Functions as a carrier to factor VIII

A

Von willebrand factor

34
Q

Adamts-13 is secreted from

A

ENDOTHELIAL CELLS

35
Q

Serves an important function as it cleaves large vWF
multimers into shorter chains that support normal platelet adhesion.

A

ADAMTS-13

36
Q

Secreted by EC

A

ADAMTS-13
P-selectin
Intercellular cell adhesion molecules (ICAMs) and Platelet endothelial cell adhesion molecules (PECAMs)

37
Q

Coats ECs

A

P-selectin

38
Q

An adhesion molecule that promotes platelet and
leukocyte-binding

A

P-selectin

39
Q

Are immunoglobulin-like adhesion molecules

A

Intercellular cell adhesion molecules (ICAMs) and Platelet endothelial cell adhesion molecules (PECAMs)

40
Q

Further promotes platelet and leukocyte binding

A

Intercellular cell adhesion molecules (ICAMs) and Platelet endothelial cell adhesion molecules (PECAMs)

41
Q

Supports the constitutive membrane protein tissue factor

A

Smooth muscle cells and fibroblasts

42
Q

Disrupted ECs exposes TF in subendothelial cells (activates the coagulation system through contact with factor VII)

A

Smooth muscle cells and fibroblasts

43
Q

White clot consists of

A

Platelet and vwf

44
Q

Bulky red clot consists of

A

Consists of platelets, vWF, fibrin, and red blood cells

45
Q

In arteries and arterioles

A

White clot

46
Q

In veins

A

Bulky red clot

47
Q

Induce vasoconstriction

A

Smooth muscle cells in arterioles and arteries

48
Q

Binds VWF; binds to and activates platelets

A

Exposed subendothelial collagen

49
Q

Important for platelet binding to collagen at site of injury: platelet adhesion as a first line of defense against bleeding

A

Damaged or activated ECs secrete VWF

50
Q

Promote platelet and leukocyte binding and activation at site of injury P-selectin, ICAMs, PECAMs

A

Damaged or activated ECs secrete adhesion molecules:

51
Q

Tissue factor exposed on cell membranes

A

Exposed smooth muscle cells
and fibroblasts

52
Q

Tissue factor is induced by inflammation

A

ECs in inflammation

53
Q

Fibrinolytic Properties of Vascular Intima

A

Tissue Plasminogen Activator (TPA)
Plasminogen Activator Inhibitor-1 PAI-1)
Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

54
Q

During thrombus formation, both TPA and plasminogen
bind to polymerized fibrin

A

Tissue Plasminogen Activator

55
Q

Activates fibrinolysis by converting plasminogen to plasmin

A

Tissue Plasminogen Activator

56
Q

A TPA control protein that inhibits plasmin generation and fibrinolysis

A

Plasminogen Activator Inhibitor-1

57
Q

Increases the tendency for thrombosis

A

Plasminogen Activator Inhibitor-1
Thrombin Activatable Fibrinolysis Inhibitor

58
Q

Can slow fibrinolysis

A

Plasminogen Activator Inhibitor-1
Thrombin Activatable Fibrinolysis
Inhibitor

59
Q

● Is activated by thrombin bound to EC membrane thrombomodulin

A

Thrombin Activatable Fibrinolysis Inhibitor

Hematology 2 PPT (3 decks)

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