Antiplatelet Drug Mechanism

Question 1

Drugs that cause platelets to activate

Answer 1

Thrombosis

Question 2

Drugs that inhibit platelet function

Answer 2

Hemmorhage

Question 3

Drugs Influencing Platelet Functions

Answer 3

1. Aspirin
2. Clopidogrel
3. Tirofiban
4. Atopaxar

Question 4

Inhibits platelet aggregation and secretion in response to ADP, Epinephrine and collagen

Answer 4

Aspirin

Question 5

inhibits prostaglandin synthesis by irreversible
acetylation and inactivation of cyclooxygenase (COX-1)

Answer 5

Aspirin

Question 6

Aspirin
inactivation of cyclooxygenase (COX-1) inhibits?

Answer 6

endoperoxide and thromboxane A2 which are
necessary for platelet secretion.

Question 7

thienopyridine derivative, binds specifically
and irreversibly to the platelet P2RY12 purinergic
receptor,

Answer 7

Clopidogrel

Question 8

irreversibly to the platelet P2RY12 purinergic
receptor inhibits?

Answer 8

ADP-mediated platelet activation and aggregation

Question 9

REMINDER‼️‼️‼️

After oral administration, clopidogrel is rapidly absorbed.

Question 10

Only reversible drug

Answer 10

TIROFIBAN

Question 11

competitive inhibitor of GP IIb/IIIa receptors

Answer 11

Tirofiban

Question 12

Tirofiban inhibits

Answer 12

GP IIB/IIIA

Question 13

Tirofiban is a reversible, competitive inhibitor of GP IIb/IIIa receptors, exerting its effects via the

Answer 13

prevention of the binding of fibrinogen and other ligands, resulting in the inhibition of platelet aggregation.

Question 14

benzimidazole derivative that can be
given orally on a once per day dose schedule.

Answer 14

Atopaxar (E5555)

Question 15

potent protease-activated receptor (PAR-1)
antagonist

Answer 15

Atopaxar (E5555)

Question 16

E5555 is a potent protease-activated receptor (PAR-1) antagonist targeting the

Answer 16

G-coupled receptor and modulating thrombin platelet-endothelial interactions.