Disadvantages of Detection Systems of Hemostatic Analyzers

Question 1

Reliance on the integrity of the entire coagulation cascade

Answer 1

Mechanical

Question 2

Inability to observe graph of clot formation

Answer 2

Mechanical

Question 3

Interference from lipemia, hemolysis, bilirubinemia, and increased plasma proteins; has been addressed by some manufacturers with readings from multiple wavelengths

Answer 3

Photo-optical

Question 4

May not detect short clotting times owing to long lag phase

Answer 4

Photo-optical

Question 5

May not detect small weak clots that are translucent

Answer 5

Photo-optical

Question 6

Limited by wavelength capabilities of some instruments

Answer 6

Chromogenic

Question 7

May need large test volume to be cost effective

Answer 7

Chromogenic

Question 8

Does not detect functional activity

Answer 8

Immunologic
Nephelometric

Question 9

Limited number of automated tests available
Higher cost of instruments and reagents

Answer 9

Immunologic
Nephelometric

Question 10

Need to have additional instruments in laboratories without automated coagulation analyzers that have random access capability

Answer 10

Immunologic

Question 11

Need for special staff training

Answer 11

Nephelometric (for immunoassays)