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GBA Immunology > Week 1 - Overview + Receptors > Flashcards

Week 1 - Overview + Receptors Flashcards

Practices and Lectures

1
Q

MHC-I-Peptide Complex:

Number of Amino Acids

A

8-9 Amino acids in peptide

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2
Q

MHC-II-Peptide Complex:

Number of Amino Acids

A

20~ Amino acids

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3
Q

What is the importance of exponential enhancement?

A

A single lymphocyte clone is equipped with a single type of antigen recognition receptor.
Therefore growth in exponential manner is Important for Immunization.

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4
Q

Clonal selection

A

When a lymphocyte encounter the specific antigen for its receptor, Then it will proliferate to form a colony with the same specificity.

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5
Q

Phases of Immune response

A

Recognition
Central
Effector

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6
Q

What happen if the Immune system deviates from Homeostasis? By order of severity

A

Stress
Para-Inflammation
Inflammation

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7
Q

What are cytokines?

A

Small soluble proteins and glycoproteins that have a messenger and regulatory function.

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8
Q

Shared features of Cytokines?

A
  • Activate Membrane receptors
  • Have translational effect oftenly
  • Functional Redundancies
  • Antagonistic, addetive and synergic effects
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9
Q

What are the general types of Cytokines?

A
  • Chemokines
  • Adipokines
  • Interleukins
  • TNF
  • IFN
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10
Q

What is the Importance of cytokines in regard to Immune sys. Homeostasis?

A

They can be either pro or anti inflammatory thus maintaining or distributing the Immune Sys. Homeostasis.

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11
Q

Hapten

A

Small molecule that only provokes Immune response if bound to large carrier molecule.

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12
Q

Secondary Antibody

A

An Antibody that recognizes the Fc portion of the first, antigen Binding Antibody.
Recognition of Fc portion as Antigen.

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13
Q

What are examples for qualitative Methods based antigen-antibody Interaction?

A

Immunofixation
Western blotting
Agglutination reactions
Lateral flow test

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14
Q

What are examples for quantitive methods based on antigen-antibody interaction?

A 
Turbidimetry
Laser nephlometery
RIA - IRMA
ELISA
Flow cytometry
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15
Q

Receptors with Specificity inherited in genome:

A
  • FC-receptors (Fraction Crystallizable)
  • Complement receptors
  • Pattern recognition receptors (PRR’s)
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16
Q

Receptors that Trigger immediate response:

A
  • FC-receptors (Fraction Crystallizable)
  • Complement receptors
  • Pattern recognition receptors (PRR’s)
17
Q

Receptors that Recognize broad classes of pathogen:

A
  • FC-receptors (Fraction Crystallizable)
  • Complement receptors
  • Pattern recognition receptors (PRR’s)
18
Q

Receptors Encoded in multiple gene segments

A
  • T-cell receptor (TCR)

- B-cell receptor (BCR)

19
Q

Receptors that Require gene rearrangement

A
  • T-cell receptor (TCR)

- B-cell receptor (BCR)

20
Q

Receptors that show with Clonal distribution

A
  • T-cell receptor (TCR)

- B-cell receptor (BCR)

21
Q

Receptors Able to recognize a wide variety of molecular structures

A
  • T-cell receptor (TCR)

- B-cell receptor (BCR)

22
Q

Receptors for regulation of natural-killer(NK) cells activity and how?

A

Killer activated receptor: KAR binds Ubiquitous Molecule on cell Surface and Killer inhibitory receptor: KIR binds MHC-I

23
Q

Rheumatoid Factor?

A

autoantibody that was first found in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG and different RFs can recognize different parts of the IgG-Fc.

24
Q

IL-1, TNF, IFN-γ, IL-12, IL-18, IL17, IL 33

These are examples for -

A

Pro-Inflammatory Cytokines

25
Q

IL-10, TGF-β , IL-13 , IFN-α, IL-35

These are examples for -

A

Anti-inflammatory Cytokines

26
Q 
Fc receptor binds
A. IgG light chains
B. Variable part of IgG
C. C terminus of IgG
D. C terminus of light chains
A

C. C terminus of IgG

27
Q 
The concentration of CRP in acute phase will:
A. increase 1.5-2-fold
B. increase 10-fold
C. increase 100-fold or more
D. Decreases
A

C. increase 100-fold or more

GBA Immunology (15 decks)

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