Week 1 - Overview + Receptors Flashcards
Practices and Lectures
MHC-I-Peptide Complex:
Number of Amino Acids
8-9 Amino acids in peptide
MHC-II-Peptide Complex:
Number of Amino Acids
20~ Amino acids
What is the importance of exponential enhancement?
A single lymphocyte clone is equipped with a single type of antigen recognition receptor.
Therefore growth in exponential manner is Important for Immunization.
Clonal selection
When a lymphocyte encounter the specific antigen for its receptor, Then it will proliferate to form a colony with the same specificity.
Phases of Immune response
Recognition
Central
Effector
What happen if the Immune system deviates from Homeostasis? By order of severity
Stress
Para-Inflammation
Inflammation
What are cytokines?
Small soluble proteins and glycoproteins that have a messenger and regulatory function.
Shared features of Cytokines?
- Activate Membrane receptors
- Have translational effect oftenly
- Functional Redundancies
- Antagonistic, addetive and synergic effects
What are the general types of Cytokines?
- Chemokines
- Adipokines
- Interleukins
- TNF
- IFN
What is the Importance of cytokines in regard to Immune sys. Homeostasis?
They can be either pro or anti inflammatory thus maintaining or distributing the Immune Sys. Homeostasis.
Hapten
Small molecule that only provokes Immune response if bound to large carrier molecule.
Secondary Antibody
An Antibody that recognizes the Fc portion of the first, antigen Binding Antibody.
Recognition of Fc portion as Antigen.
What are examples for qualitative Methods based antigen-antibody Interaction?
Immunofixation
Western blotting
Agglutination reactions
Lateral flow test
What are examples for quantitive methods based on antigen-antibody interaction?
Turbidimetry Laser nephlometery RIA - IRMA ELISA Flow cytometry
Receptors with Specificity inherited in genome:
- FC-receptors (Fraction Crystallizable)
- Complement receptors
- Pattern recognition receptors (PRR’s)
Receptors that Trigger immediate response:
- FC-receptors (Fraction Crystallizable)
- Complement receptors
- Pattern recognition receptors (PRR’s)
Receptors that Recognize broad classes of pathogen:
- FC-receptors (Fraction Crystallizable)
- Complement receptors
- Pattern recognition receptors (PRR’s)
Receptors Encoded in multiple gene segments
- T-cell receptor (TCR)
- B-cell receptor (BCR)
Receptors that Require gene rearrangement
- T-cell receptor (TCR)
- B-cell receptor (BCR)
Receptors that show with Clonal distribution
- T-cell receptor (TCR)
- B-cell receptor (BCR)
Receptors Able to recognize a wide variety of molecular structures
- T-cell receptor (TCR)
- B-cell receptor (BCR)
Receptors for regulation of natural-killer(NK) cells activity and how?
Killer activated receptor: KAR binds Ubiquitous Molecule on cell Surface and Killer inhibitory receptor: KIR binds MHC-I
Rheumatoid Factor?
autoantibody that was first found in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG and different RFs can recognize different parts of the IgG-Fc.
IL-1, TNF, IFN-γ, IL-12, IL-18, IL17, IL 33
These are examples for -
Pro-Inflammatory Cytokines
IL-10, TGF-β , IL-13 , IFN-α, IL-35
These are examples for -
Anti-inflammatory Cytokines
Fc receptor binds A. IgG light chains B. Variable part of IgG C. C terminus of IgG D. C terminus of light chains
C. C terminus of IgG
The concentration of CRP in acute phase will: A. increase 1.5-2-fold B. increase 10-fold C. increase 100-fold or more D. Decreases
C. increase 100-fold or more
