Cell Surface Markers Flashcards
Natural Killer Cells - Surface Markers
CD16 (Fc binding of IgG)
CD3-
CD56+
Lymphoid Progenitor - Surface Markers
CD34+
TdT+
Pro-T cells - Surface Markers
CD3+
CD5+ or CD5-
CD7+
B-cell - Surface Markers
CD19+ CD20+ CD21+ CD40+ MHCII, B7 (CD80/86)
B1 Cell - Surface Markers
CD5+
B2 Cell - Surface Markers
CD5-
Plasma Cell - Surface Markers
CD19+
IC Light Chain+
T Helper cell (all types) - Surface Markers
CD4+
CD40L+(CD154)
CD3+
CXCR4+/CCR5+ (HIV co-receptors)
Th17 cell - Surface Markers
CD3+
CD4+
IL-17RA+
RORγ+ - TF
Th22 Cell - Surface Markers
CD3+
CD4+
IL-22RA+
Th2 Cell - Surface Markers
CD3+
CD4+
GATA3+ - TF
(IL4+, IL5+, IL13+)
Th1 Cell - Surface Markers
CD3+
CD4+
T-Bet+ - TF
(IFN-γ+, IL12+, TNF-alpha and TNF-beta +)
Treg cell - Surface Markers
CD4+
CD25(high)+
Foxp3+
Cytotoxic T cell - Surface Markers
CD8+
CD3+
(CD5+ , CD2+ , CD7+, CD38+)
γ-𝛿-T cell - Surface Markers
CD3+
γ𝛿TCR+
CD4-
CD8-
T cells (All types) - Surface Markers
TCR
CD3+
CD28+ (Binds to B7 on APC)
Macrophages - Surface Markers
CD14+ (for PAMPS) CD40+ CCR5+ MHCII, B7 (CD80/86) Fc and C3b receptors (Opsonins)
On which cells can we find CD3 Surface Marker?
T cells
On which cells can we find CD28 Surface Marker?
T cells, Plasma cells and NK cells
On which cells can we find B7 Surface Marker?
APCs: Macrophages, Dendritic cells and B cells.
On which cells can we find CD4 Surface Marker?
T Helper cells and T regulatory cells
On which cells can we find CD40L (CD154) Surface Marker?
T Helper cells
On which cells can we find CXCR4 Surface Marker?
T Helper cells
On which cells can we find CCR5 Surface Marker?
T Helper cells and Macrophages
On which cells can we find CD8 Surface Marker?
Cytotoxic T cells
On which cells can we find CD40 Surface Marker?
T cell -B cell Costimulation (sometimes T+Macrophages)
B cells and Macrophages
On which cells can we find CD19, CD20, CD21 Surface Markers?
B cells
On which cells can we find CD14 Surface Marker?
Macrophages and Granulocytes
On which cells can we find CD80 Surface Marker?
Antigen Presenting Cells
DC, B cells and Macrophages
(B7)
On which cells can we find CD86 Surface Marker?
Antigen Presenting Cells
DC, B cells and Macrophages
(B7)
On which cells can we find CD16 Surface Marker?
NK Cells
On which cells can we find CD56 Surface Marker?
NK Cells
On which cells can we find CD34 and cKit (CD117)+ Surface Marker?
HSCs
HLA-A, HLA-B and HLA-C (HLA-E, F and G as well)
Where are they found?
MHC Class I Subtypes
Meaning all Nucleated cells
HLA-DP, HLA-DQ, and HLA-DR (HLA-DM and DO as well) Where are they found?
MHC Class II Subtypes
Meaning all APCs
Important KIR (Killing Inhibitory Receptor) Example What does it bind?
NKG2A
Binds MHC-I
Important KAR (Killing Activation Receptor) Example What does it bind?
NKG2D
Binds MICA,MICB and ULBP (Ubiquitous
“Stress” Molecules)
Immunological Synapse:
CD80/CD86 -(B7s) on DC are interacting with which counterpart on the T cell?
CD28
Immunological Synapse:
MHC-II (or I) with Peptide on DC are interacting with which counterparts on the T cell?
TCR+CD3 with CD4 (or CD8 in Cross presentation)
Costimulation of B and T cells: 2nd Signal
CD154 (CD40L) on T cell are interacting with which counterparts on the B cell?
CD40
Myeloid Progenitor - Markers
CD34+
MPO+
Neutrophills - Surface Marker
CD15+
Megakaryocyte- Surface Marker
CD41+
