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GBA Immunology > Cell Surface Markers > Flashcards

Cell Surface Markers Flashcards

1
Q

Natural Killer Cells - Surface Markers

A

CD16 (Fc binding of IgG)
CD3-
CD56+

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2
Q

Lymphoid Progenitor - Surface Markers

A

CD34+

TdT+

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3
Q

Pro-T cells - Surface Markers

A

CD3+
CD5+ or CD5-
CD7+

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4
Q

B-cell - Surface Markers

A 
CD19+
CD20+
CD21+
CD40+
MHCII, B7 (CD80/86)
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5
Q

B1 Cell - Surface Markers

A

CD5+

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6
Q

B2 Cell - Surface Markers

A

CD5-

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7
Q

Plasma Cell - Surface Markers

A

CD19+

IC Light Chain+

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8
Q

T Helper cell (all types) - Surface Markers

A

CD4+
CD40L+(CD154)
CD3+
CXCR4+/CCR5+ (HIV co-receptors)

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9
Q

Th17 cell - Surface Markers

A

CD3+
CD4+
IL-17RA+
RORγ+ - TF

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10
Q

Th22 Cell - Surface Markers

A

CD3+
CD4+
IL-22RA+

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11
Q

Th2 Cell - Surface Markers

A

CD3+
CD4+
GATA3+ - TF
(IL4+, IL5+, IL13+)

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12
Q

Th1 Cell - Surface Markers

A

CD3+
CD4+
T-Bet+ - TF
(IFN-γ+, IL12+, TNF-alpha and TNF-beta +)

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13
Q

Treg cell - Surface Markers

A

CD4+
CD25(high)+
Foxp3+

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14
Q

Cytotoxic T cell - Surface Markers

A

CD8+
CD3+
(CD5+ , CD2+ , CD7+, CD38+)

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15
Q

γ-𝛿-T cell - Surface Markers

A

CD3+
γ𝛿TCR+
CD4-
CD8-

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16
Q

T cells (All types) - Surface Markers

A

TCR
CD3+
CD28+ (Binds to B7 on APC)

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17
Q

Macrophages - Surface Markers

A 
CD14+ (for PAMPS)
CD40+
CCR5+
MHCII, B7 (CD80/86)
Fc and C3b receptors (Opsonins)
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18
Q

On which cells can we find CD3 Surface Marker?

A

T cells

19
Q

On which cells can we find CD28 Surface Marker?

A

T cells, Plasma cells and NK cells

20
Q

On which cells can we find B7 Surface Marker?

A

APCs: Macrophages, Dendritic cells and B cells.

21
Q

On which cells can we find CD4 Surface Marker?

A

T Helper cells and T regulatory cells

22
Q

On which cells can we find CD40L (CD154) Surface Marker?

A

T Helper cells

23
Q

On which cells can we find CXCR4 Surface Marker?

A

T Helper cells

24
Q

On which cells can we find CCR5 Surface Marker?

A

T Helper cells and Macrophages

25
Q

On which cells can we find CD8 Surface Marker?

A

Cytotoxic T cells

26
Q

On which cells can we find CD40 Surface Marker?

A

T cell -B cell Costimulation (sometimes T+Macrophages)

B cells and Macrophages

27
Q

On which cells can we find CD19, CD20, CD21 Surface Markers?

A

B cells

28
Q

On which cells can we find CD14 Surface Marker?

A

Macrophages and Granulocytes

29
Q

On which cells can we find CD80 Surface Marker?

A

Antigen Presenting Cells
DC, B cells and Macrophages
(B7)

30
Q

On which cells can we find CD86 Surface Marker?

A

Antigen Presenting Cells
DC, B cells and Macrophages
(B7)

31
Q

On which cells can we find CD16 Surface Marker?

A

NK Cells

32
Q

On which cells can we find CD56 Surface Marker?

A

NK Cells

33
Q

On which cells can we find CD34 and cKit (CD117)+ Surface Marker?

A

HSCs

34
Q

HLA-A, HLA-B and HLA-C (HLA-E, F and G as well)

Where are they found?

A

MHC Class I Subtypes

Meaning all Nucleated cells

35
Q

HLA-DP, HLA-DQ, and HLA-DR (HLA-DM and DO as well) Where are they found?

A

MHC Class II Subtypes

Meaning all APCs

36
Q 
Important KIR (Killing Inhibitory Receptor) Example 
What does it bind?
A

NKG2A

Binds MHC-I

37
Q 
Important KAR (Killing Activation Receptor) Example 
What does it bind?
A

NKG2D
Binds MICA,MICB and ULBP (Ubiquitous
“Stress” Molecules)

38
Q

Immunological Synapse:

CD80/CD86 -(B7s) on DC are interacting with which counterpart on the T cell?

A

CD28

39
Q

Immunological Synapse:

MHC-II (or I) with Peptide on DC are interacting with which counterparts on the T cell?

A

TCR+CD3 with CD4 (or CD8 in Cross presentation)

40
Q

Costimulation of B and T cells: 2nd Signal

CD154 (CD40L) on T cell are interacting with which counterparts on the B cell?

A

CD40

41
Q

Myeloid Progenitor - Markers

A

CD34+

MPO+

42
Q

Neutrophills - Surface Marker

A

CD15+

43
Q

Megakaryocyte- Surface Marker

A

CD41+

GBA Immunology (15 decks)

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